METHOD AND DEVICE FOR CARDIOSYMPATHETIC INHIBITION
First Claim
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1. An implantable device, comprising:
- a pulse generator for outputting neural stimulation pulses;
one or more stimulation electrodes connected to the pulse generator for delivering electrical stimulation to a selected neural site, wherein the stimulation electrodes are adapted for disposition near the left stellate ganglion of a patient;
a controller connected to the pulse generator for controlling the output of neural stimulation pulses in a manner that inhibits cardiosympathetic activity by acting on the left stellate ganglion;
wherein the controller is programmed to neural stimulation pulses according to a duty cycle that alternates between a neural stimulation state and a non-neural stimulation state in accordance with one or more defined entry and exit conditions;
one or more sensors connected to the controller for sensing one or more physiological variables related to an increased risk of sudden cardiac death; and
,wherein the controller is programmed to transition to the neural stimulation state and deliver neural stimulation that inhibits cardiosympathetic activity according to an entry condition defined as when the one or more physiological variables indicate that the patient is at increased risk for sudden cardiac death.
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Abstract
Described herein are methods and devices that utilize electrical neural stimulation for inhibiting cardiosympathetic activity in order to reduce the risk of sudden cardiac death. In one embodiment, one or more stimulating electrodes are disposed near the left stellate ganglion. An implantable pulse generator delivers neural stimulation to the electrodes in a manner that inhibits activity of the ganglionic tissue.
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Citations
20 Claims
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1. An implantable device, comprising:
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a pulse generator for outputting neural stimulation pulses; one or more stimulation electrodes connected to the pulse generator for delivering electrical stimulation to a selected neural site, wherein the stimulation electrodes are adapted for disposition near the left stellate ganglion of a patient; a controller connected to the pulse generator for controlling the output of neural stimulation pulses in a manner that inhibits cardiosympathetic activity by acting on the left stellate ganglion; wherein the controller is programmed to neural stimulation pulses according to a duty cycle that alternates between a neural stimulation state and a non-neural stimulation state in accordance with one or more defined entry and exit conditions; one or more sensors connected to the controller for sensing one or more physiological variables related to an increased risk of sudden cardiac death; and
,wherein the controller is programmed to transition to the neural stimulation state and deliver neural stimulation that inhibits cardiosympathetic activity according to an entry condition defined as when the one or more physiological variables indicate that the patient is at increased risk for sudden cardiac death. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. An implantable device, comprising:
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a pulse generator for outputting neural stimulation pulses; a grid array incorporating a plurality of stimulation electrodes connectable to the pulse generator for delivering electrical stimulation to a selected neural site, wherein the grid array is adapted for disposition near the left stellate ganglion of a patient; a controller connected to the pulse generator for controlling the output of neural stimulation pulses in a manner that inhibits cardiosympathetic activity by acting on the left stellate ganglion; a telemetry transceiver interfaced to the controller; and
,wherein the controller is programmed to configure neural stimulation channels with one or more electrodes of the grid array by operating a switch matrix in accordance with commands received via the telemetry transceiver. - View Dependent Claims (9, 10, 11)
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12. A method, comprising:
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implanting a pulse generator connected to one or more neural stimulation electrodes; implanting the one or more stimulation electrodes near the left stellate ganglion of a patient; and
,delivering neural stimulation pulses from the pulse generator to the left stellate ganglion in a manner that inhibits cardiosympathetic activity. - View Dependent Claims (13, 14, 15, 16, 17, 18, 19, 20)
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Specification