CARDIOPULMONARY FUNCTIONAL STATUS ASSESSMENT VIA METABOLIC RESPONSE DETECTION BY IMPLANTABLE CARDIAC DEVICE

• US 20080249586A1
• Filed: 06/16/2008
• Published: 10/09/2008
• Est. Priority Date: 08/12/2004
• Status: Active Grant

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Morris, Richard, Hopper, Donald L., Wilkoff, Bruce
• Granted Patent: US 8,116,869 B2
• Time in Patent Office: Days
• US Class Current: 607/19
• CPC Class Codes: A61N 1/365 controlled by a physiological parameter, e.g. heart potential evoked response A61N1/371
• CPC Class Codes: A61N 1/36521 the parameter being derived from measurement of an electrical impedance
• CPC Class Codes: A61N 1/36542 controlled by body motion, e.g. acceleration
• CPC Class Codes: A61N 1/36585 controlled by two or more physical parameters
• CPC Class Codes: A61N 1/3702 Physiological parameters A61N1/365 takes precedence; evoked response A61N1/371

Abstract

An implantable cardiac device is configured and programmed to assess a patient'"'"'s cardiopulmonary function by evaluating the patient'"'"'s minute ventilation response. Such evaluation may be performed by computing a minute ventilation response slope, defined as the ratio of an incremental change in minute ventilation to an incremental change in measured activity level. The minute ventilation response slope may then be compared with a normal range to assess the patient'"'"'s functional status.

Claims

1. An implantable medical device, comprising:

a controller;

one or more sensing/pacing channels, wherein the controller is programmed to control the delivery of pacing pulses in accordance with an atrial-triggered mode such that a ventricular pace is delivered upon expiration of an escape interval designated as the AV delay interval;

a minute ventilation sensor interfaced to the controller;

an activity level sensor interfaced to the controller for measuring a parameter related to a patient'"'"'s level of physical activity;

wherein the controller is programmed to construct a historical record of activity level versus minute ventilation, referred to as a minute ventilation response profile;

wherein the controller is further programmed to monitor a patient'"'"'s cardiopulmonary functional status by computing a minute ventilation response slope from the minute ventilation response profile, defined as the ratio of an incremental change in minute ventilation to an incremental change in measured activity level, and compare the minute ventilation response slope to a specified limit value; and

,

wherein the controller is further programmed to decrease a lower rate limit interval upon detecting that the patient'"'"'s minute ventilation response slope has worsened to a specified extent.

2. The device of claim 1 wherein the minute ventilation response profile is a data structure containing a plurality of minute ventilations, each minute ventilation being associated with a discrete activity level.

3. The device of claim 2 wherein the minute ventilation response profile is updated by averaging a currently measured minute ventilation over an N second interval and associating the averaged minute ventilation with an activity level corresponding to an average of a currently measured activity level over the N second interval.

4. The device of claim 3 wherein the minute ventilation response profile is updated only if activity level measurements taken over the N second interval meet a predefined stability criterion.

5. The device of claim 4 wherein the predefined stability criterion comprises computing a statistic of the measurements and comparing the statistic with a limit value.

6. The device of claim 1 wherein the controller is programmed to set an alarm flag if the minute ventilation response slope is not within a normal range as defined by upper and lower limit values.

7. The device of claim 6 further comprising:

a telemetry interface for communicating with a remote monitoring device; and

,

wherein the controller is programmed to send an alert message via the telemetry interface if an alarm flag is set.

8. The device of claim 1 wherein the controller is further programmed to adjust the AV delay interval upon detecting that the patient'"'"'s minute ventilation response slope has changed to a specified extent.

9. The device of claim 1 wherein the controller is further programmed to adjust a rate-response factor used in rate-adaptive pacing so as to increase the frequency of pacing upon detection of an increased minute ventilation response slope.

10. The device of claim 1 further comprising:

sensing/pacing channels for delivering cardiac resynchronization pacing in the form of biventricular pacing with a specified biventricular offset interval; and

,

wherein the controller is further programmed to adjust the biventricular offset interval upon detection of a change in the minute ventilation response slope to a specified extent.

11. A method for operating an implantable medical device, comprising:

delivering pacing pulses in accordance with an atrial-triggered mode such that a ventricular pace is delivered upon expiration of an escape interval designated as the AV delay interval;

measuring a parameter related to a patient'"'"'s level of physical activity;

measuring a patient'"'"'s minute ventilation;

constructing a historical record of activity level versus minute ventilation, referred to as a minute ventilation response profile;

monitoring a patient'"'"'s cardiopulmonary functional status by computing a minute ventilation response slope from the minute ventilation response profile, defined as the ratio of an incremental change in minute ventilation to an incremental change in measured activity level, and comparing the minute ventilation response slope to a specified limit value; and

,

decreasing a lower rate limit interval upon detecting that the patient'"'"'s minute ventilation response slope has worsened to a specified extent.

12. The method of claim 11 wherein the minute ventilation response profile is a data structure containing a plurality of minute ventilations, each minute ventilation being associated with a discrete activity level.

13. The method of claim 12 wherein the minute ventilation response profile is updated by averaging a currently measured minute ventilation over an N second interval and associating the averaged minute ventilation with an activity level corresponding to an average of a currently measured activity level over the N second interval.

14. The method of claim 13 wherein the minute ventilation response profile is updated only if activity level measurements taken over the N second interval meet a predefined stability criterion.

15. The device of claim 14 wherein the predefined stability criterion comprises computing a statistic of the measurements and comparing the statistic with a limit value.

16. The method of claim 11 further comprising setting an alarm flag if the minute ventilation response slope is not within a normal range as defined by upper and lower limit values.

17. The method of claim 16 further comprising send an alert message via a telemetry interface if an alarm flag is set.

18. The method of claim 11 further comprising adjusting the AV delay interval upon detecting that the patient'"'"'s minute ventilation response slope has changed to a specified extent.

19. The method of claim 11 further comprising adjusting a rate-response factor used in rate-adaptive pacing so as to increase the frequency of pacing upon detection of an increased minute ventilation response slope.

20. The method of claim 11 further comprising:

delivering cardiac resynchronization pacing in the form of biventricular pacing with a specified biventricular offset interval; and

,

adjusting the biventricular offset interval upon detection of a change in the minute ventilation response slope to a specified extent.