Skin Antiaging & Brightening via Multi-function Treatment of Enzyme Dysfunction

• US 20080254130A1
• Filed: 06/14/2008
• Published: 10/16/2008
• Est. Priority Date: 08/29/2003
• Status: Abandoned Application

• Current Assignee: Bioderm Research
• Original Assignee: Bioderm Research
• Inventors: GUPTA, SHYAM K.
• Application Number:
  US12/139,462
• Publication Number:
  US 20080254130A1
• Time in Patent Office: Days
• US Class Current: 424/489
• CPC Class Codes: A61K 2800/522 Antioxidants; Radical scavengers
• CPC Class Codes: A61K 2800/78 Enzyme modulators, e.g. Enzyme agonists
• CPC Class Codes: A61K 8/35 Ketones, e.g. benzophenone
• CPC Class Codes: A61K 8/498 having 6-membered rings or their condensed derivatives, e.g. coumarin
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61Q 19/02 for chemically bleaching or whitening the skin
• CPC Class Codes: A61Q 19/08 Anti-ageing preparations

Abstract

The present invention relates to a topical method of treatment for dysfunction of certain dermal enzymes, and the treatment of skin condition or disorder caused by said dysfunction. The said method of treatment consists of (i) an extra-cellular, matrix metalloprotease regulating agent, and (ii) an intra-cellular ubiquitin—proteasome regulating agent, and (iii) an epidermal melanocyte-regulating agent; and, wherein, said extra-cellular agent, said intracellular agent, and said epidermal agent can, surprisingly and unexpectedly, be a single multi-function compound having chemical formula (I). Additionally, the method of the present invention provides treatment of skin condition or disorder caused by dysfunction of said dermal enzymes; wherein said skin disorder is skin aging, skin wrinkles, dark skin, age spots, acne, skin inflammation, loss of cellular antioxidants, loss of collagen, loss of skin pliability, loss of skin suppleness, oily skin, or a combination thereof:

Claims

1. A topical method of treatment for dysfunction of dermal enzymes comprising;

(i) An Extra-cellular, Matrix metalloprotease regulating agent, and

(ii) An Intra-cellular Ubiquitin—

Proteasome regulating agent, and

(iii) An epidermal melanocyte-regulating agent, and, wherein,

(iv) Said extra-cellular agent, said intracellular agent, and said epidermal agent is a multi-function hydroxyaryl compound in accordance to formula (I);

2. A method according to claim 1, wherein said multi-function compound is Resacetophenone.

3. A method according to claim 1, wherein said dysfunction consists of a combination of Matrix Metalloproteases, Ubiquitin—

Proteasomes, and epidermal Melanocytes.

4. A method according to claim 1, wherein said multi-function compound is further selected from the group consisting of Resacetophenone, 2-hydroxyacetophenone, 3-hydroxyacetophenone, 4-hydroxyacetophenone, 2,3-dihydroxyacetophenone, 2,5-dihydroxyacetophenone, 2,6-dihydroxyacetophenone, 3,4-dihydroxyacetophenone, 3,5-dihydroxyacetophenone, 2,4,6-trihydroxyacetophenone, 2,3,4-trihydroxyacetophenone, 2,3,5-trihydroxyacetophenone, 2,3,6-trihydroxyacetophenone, 2,4,5-trihydroxyacetophenone, 3,4,5-trihydroxyacetophenone, 2-Acetyl resorcinol, 4-Acetyl resorcinol, 3,4-Dihydroxyacetophenone, Quinacetophenone, 1-(3-Hydroxy-4-methoxy-5-methylphenyl)ethanone, 1-(3-hydroxy-4-methoxyphenyl)ethanone, Paeonol, 5′

-Bromo-2′

-hydroxyacetophenone, 5′

-Chloro-2′

-hydroxyacetophenone, 3′

,5′

-Dichloro-2′

-hydroxyacetophenone, 3′

,5′

-Dibromo-4′

-hydroxyacetophenone, 5-Chloro-3-bromo-2-hydroxyacetophenone, 2-hydroxypropiophenone, 3-hydroxypropiophenone, 4-hydroxypropiophenone, 2,3-dihydroxypropiophenone, 2,4-dihydroxypropiophenone, 2,5-dihydroxypropiophenone, 2,6-dihydroxypropiophenone, 3,4-dihydroxypropiophenone, 3,5-dihydroxypropiophenone, 2,4,6-trihydroxypropiophenone, 2,3,4-trihydroxypropiophenone, 2,3,5-trihydroxypropiophenone, 2,3,6-trihydroxypropiophenone, 2,4,5-trihydroxypropiophenone, 3,4,5-trihydroxypropiophenone, phloridzin, phloretin, 1-(2,4-dihydroxyphenyl)-2-hydroxyethanone, (2-hydroxyphenyl)(oxo)acetic acid, 1-(2,6-dihydroxyphenyl)-1-butanone, 1-(1-hydroxy-2-naphthyl)ethanone, 1-(2-hydroxy-1-naphthyl)ethanone, 5,7-dihydroxy-1-indanone, 1-(2-hydroxy-5-methylphenyl)-1,3-butanedione, N-(4-acetyl-3-hydroxyphenyl)acetamide, 4-acetyl-3-hydroxyphenyl acetate, 1,1′

-(4,6-Dihydroxy-1,3-phenylene)bisethanone, 1-(1-hydroxy-2-naphthyl)ethanone, 2,3-Dihydro-9,10-dihydroxy-1,4-anthracenedione, 1-hydroxy-2-acetylnaphthalene;

1-hydroxy-2-acetyl-5,6,7,8-tetrahydro-naphthalene;

7-acetyl-8-hydroxyquinoline;

3-acetyl-4-hydroxyacridine;

6-acetyl-7-hydroxybenzothiazole, 2-acetylpyridine, 2-acetylpyrrole, 2-acetylimidazole, 2-acetylthiazole, 2-acetylpyrimidine, 2-acetylindole, 2-acetyl-1-methylpyrrole, 2-acetyl-4-methylpyridine, 1-acetylphenothiazine, 2-hydroxy-1-acetylphenothiazine, 8-hydroxy-9-acetylphenanthrene, 2-acetylpyrazine, 2-acetylquinoline, 2-acetyl-8-hydroxyquinoline, 2-acetyltryptophane, 2-acetyltryptophanamide, 2-acetylpyridine N-oxide, 2-acetylquinazoline, 2-acetylquinoxaline, 3-acetylpyridazine, 6,6′

-diacetyl-2,2′

-pyridyl, 3-actyl-1,2,4-trizol, and combinations thereof.

5. A method according to claim 1, wherein a carrier base or delivery system is included.

6. A method according to claim 1, wherein said topical method of treatment is for skin condition or disorder caused by dysfunction of said enzymes.

7. A method according to claim 4, wherein said compound is Resacetophenone.

8. A method according to claim 4, wherein said compound is Phloridzin.

9. A method according to claim 5, wherein said carrier base is selected from the group consisting of a lotion, cream, gel, spray, thin liquid, body splash, powder, compressed powder, tooth paste, tooth powder, mouth spray, paste dentifrice, clear gel dentifrice, mask, serum, solid cosmetic stick, lip balm, shampoo, liquid soap, bar soap, bath oil, paste, salve, collodion, impregnated patch, impregnated strip, skin surface implant, impregnated or coated diaper, and combinations thereof.

10. A method according to claim 5, wherein said delivery system is selected from the group consisting of a traditional water and oil emulsions, suspensions, colloids, microemulsions, clear solutions, suspensions of nanoparticles, emulsions of nanoparticles, anhydrous compositions, and combinations thereof.

11. A method according to claim 6, wherein said skin condition or disorder is further selected from the group consisting of skin aging, skin wrinkles, dark skin, age spots, acne, skin inflammation, loss of cellular antioxidants, loss of collagen, loss of skin pliability, loss of skin suppleness, oily skin, or a combination thereof.

12. A method according to claim 6, wherein said skin condition or disorder is skin wrinkles.

13. A method according to claim 6, wherein said skin condition or disorder is dark skin.

14. A method according to claim 9, wherein said carrier base is a cream.

15. A method according to claim 10, wherein said delivery system is an anhydrous composition.

16. A method according to claim 11, wherein said skin condition or disorder is skin wrinkles.

17. A method according to claim 11, wherein said skin condition or disorder is dark skin.