METHOD FOR INDUCING A CELL-MEDIATED IMMUNE RESPONSE AND IMPROVED PARENTERAL VACCINE FORMULATIONS THEREOF
First Claim
1. A method of inducing a TH2 polarised immune response to an antigen, comprising parenterally administering to a subject nanoparticles sized such that at least 50% of the nanoparticles are less than 600 nm, the nanoparticles comprising the antigen entrapped or encapsulated by a biodegradable polymer.
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Abstract
A method of inducing either a TH1 polarised immune response, a TH2 polarised immune response or a combined TH1 and TH2 response to an antigen and associated vaccine formulations are disclosed. A method is provided for inducing a polarised TH1 response by parenteral administration of microparticles sized such that at least 50% of the microparticles are less than 5 μm, the microparticles containing antigen entrapped or encapsulated by a biodegradable polymer. Additionally, a method is provided for inducing a polarised TH2 response by parenteral administration of nanoparticles sized such that at least 50% of the nanoparticles are less than 600 nm, the nanoparticles containing antigen entrapped or encapsulated by a biodegradable polymer. Vaccine formulations containing the B. pertussis antigens PTd, FHA or a combination of PTd and FHA are provided.
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Citations
6 Claims
- 1. A method of inducing a TH2 polarised immune response to an antigen, comprising parenterally administering to a subject nanoparticles sized such that at least 50% of the nanoparticles are less than 600 nm, the nanoparticles comprising the antigen entrapped or encapsulated by a biodegradable polymer.
Specification