Management of dermatitic symptoms of mammalian integument with emollient disinfectant formulations

• US 20080254150A1
• Filed: 03/31/2008
• Published: 10/16/2008
• Est. Priority Date: 01/03/2000
• Status: Abandoned Application

• Current Assignee: International Flora Technologies Limited
• Original Assignee: International Flora Technologies Limited
• Inventors: Ashley, David, Brown, James S., Brown, James H., Reinhardt, John, Rheins, Lawrence A., Hill, John C.
• Application Number:
  US12/080,070
• Publication Number:
  US 20080254150A1
• Time in Patent Office: Days
• US Class Current: 424/725
• CPC Class Codes: A61K 36/185 Magnoliopsida (dicotyledons)
• CPC Class Codes: A61K 36/61 Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
• CPC Class Codes: A61K 8/042 Gels
• CPC Class Codes: A61K 8/361 Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
• CPC Class Codes: A61K 8/922 of vegetable origin
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61Q 17/005 Antimicrobial preparations
• CPC Class Codes: A61Q 19/00 Preparations for care of the skin
• CPC Class Codes: A61Q 19/10 Washing or bathing preparations
• CPC Class Codes: A61Q 9/02 Shaving preparations

Abstract

Botanically-sourced and botanically-derived emollient sanitation compositions for topical use are disclosed. Representative compositions generally aid reconstitution of the lipid profile of the stratum corneum by providing botanical lipids and/or lipid-derivatives that resemble human sebum—these components being ordinarily diminished with the use of conventional hand sanitizer products. Disclosed features and specifications may be variously controlled, adapted or optionally modified to realize, for example, improved hand sanitizer formulations. Representative embodiments of the present invention generally provide anti-microbial compositions blended with botanically sourced lipids and/or lipid-derivatives to control or otherwise improve dermatitic symptoms associated with frequent use of conventional hand sanitizer products.

Claims

1. A composition for topical application to the skin of a mammalian subject, said composition comprising an anti-microbial sanitizer and at least one of a botanically-sourced and a botanically-derived emollient, wherein said emollient has a lipid profile substantially similar to that of mammalian sebum.

2. The composition of claim 1, wherein said anti-microbial sanitizer comprises at least one of an alcohol, chlorhexidine gluconate, benzalkonium chloride, iodine, grapeseed oil, lemon juice, tea tree oil, citronellol, camphor oil, cade oil, eucalyptol, clove oil, a dermatological active agent, a pharmaceutical composition, an antibiotic, a bactericidal agent, an antiseptic agent, a disinfectant agent, an antiviral agent, a nitrogenous cationic surface-active agent, a fruit juice, and a fruit extract.

3. The composition of claim 2, wherein said alcohol comprises at least one of ethanol, isopropyl alcohol, and a denatured alcohol.

4. The composition of claim 1, wherein said composition is certified as organic.

5. The composition of claim 1, wherein said anti-microbial sanitizer comprises at least one of:

at least about 60% (wt/wt) ethanol, and at least about 60% (v/v) ethanol.

6. The composition of claim 1, wherein said emollient comprises at least one of jojoba oil, an extract of jojoba, a derivative of jojoba oil, a derivative of a jojoba extract, and a humectant.

7. The composition of claim 6, wherein the derivative of at least one of said jojoba oil and said jojoba extract comprise at least one of a jojoba ester, hydrogenated jojoba oil, a jojoba hydrolysate, a hydrolyzed jojoba ester, a jojoba alcohol, an alkoxylated jojoba wax, an alkoxylated and at least partially hydrogenated jojoba wax, an alkoxylated product of jojoba oil interesterified with hydrogenated jojoba oil, and an isopropyl jojobate.

8. The composition of claim 6, wherein said emollient further comprises at least one of:

about 5%-35% (wt/wt) water;

about 0.1% (wt/wt) PEG-150 hydrogenated jojoba;

about 0.15%-0.25% (wt/wt) polyacrylic acid polymer;

about 0.5%-5% (wt/wt) glycerin;

about 1%-2% (wt/wt) of at least one of isopropyl jojobate, a jojoba alcohol, a jojoba ester, and tocopherol acetate;

about 1.4% (wt/wt) ethyl macadamiate;

about 0.1% (wt/wt) of an unsaponifiable fraction of olive oil hydrolysate;

about 0.1% (wt/wt) bisabolol;

about 0.1% (wt/wt) of at least one of a hydrolyzed jojoba ester, a jojoba ester, and water;

about 2%-2.5% (wt/wt) of at least one of acrylamide, sodium acryloyldimethyl taurate copolymer, isohexadecane, and polysorbate 80;

about 0.6%-1% (wt/wt) of at least one of a jojoba ester, a hydrogenated jojoba oil, and tocopherol acetate;

up to about 0.06% (wt/wt) triethanolamine;

a fragrance; and

a preservative.

9. The composition of claim 1, wherein said emollient comprises at least one of a carrier particle and glycerin.

10. The composition of claim 1, further comprising an additive selected from the group consisting of:

a coloring agent, a dye, a color-shifting pigment, a preservative, a pH modifier, a weak base, a pH buffering agent, a thickening agent, a polymer, a fragrance, a polar extract of a fragrance, water, a polyacrylic acid, a sugar alcohol, glitter, a special effect pigment, a vitamin, a pro-vitamin, an amino acid, a protein, a peptide, a peptide complex, and an active agent.

11. The composition of claim 1, wherein said composition is formulated into at least one of a soap, a body wash, a stringent, a toner, a freshener, a gel, a towelette, a napkin, a feminine hygiene product, and a wipe.

12. The composition of claim 1, wherein said composition provides at least one of:

improvement of the function of the stratum corneum, reduction in transepidermal water loss, improved substantive feel, and improved moisturizing feel.

13. A moisturizing and sanitizing composition for topical application to the skin of a mammalian subject, said composition comprising an anti-microbial sanitizer and an emollient selected from the group consisting of jojoba oil, a jojoba ester, hydrogenated jojoba oil, a jojoba hydrolysate, a hydrolyzed jojoba ester, a jojoba alcohol, an alkoxylated jojoba wax, an alkoxylated and at least partially hydrogenated jojoba wax, an alkoxylated product of jojoba oil interesterified with hydrogenated jojoba oil, an isopropyl jojobate, and a humectant.

14. The composition of claim 13, wherein the emollient'"'"'s lipid profile substantially corresponds to the lipid profile of mammalian sebum.

15. The composition of claim 13, wherein said anti-microbial sanitizer comprises at least one of an alcohol, chlorhexidine gluconate, benzalkonium chloride, iodine, grapeseed oil, lemon juice, tea tree oil, citronellol, camphor oil, cade oil, eucalyptol, clove oil, a dermatological active agent, a pharmaceutical composition, an antibiotic, a bactericidal agent, an antiseptic agent, a disinfectant agent, a nitrogenous cationic surface-active agent, a fruit juice, and a fruit extract.

16. The composition of claim 15, wherein said alcohol comprises at least one of ethanol, isopropyl alcohol, and a denatured alcohol.

17. The composition of claim 13, wherein said composition is certified as organic.

18. The composition of claim 13, wherein said anti-microbial sanitizer comprises at least one of:

at least about 60% (wt/wt) ethanol, and at least about 60% (v/v) ethanol.

19. The composition of claim 13, wherein said emollient further comprises at least one of:

about 5%-35% (wt/wt) water;

about 0.1% (wt/wt) PEG-150 hydrogenated jojoba;

about 0.15%-0.25% (wt/wt) polyacrylic acid polymer;

about 0.5%-5% (wt/wt) glycerin;

about 1%-2% (wt/wt) of at least one of isopropyl jojobate, a jojoba alcohol, a jojoba ester, and tocopherol acetate;

about 1.4% (wt/wt) ethyl macadamiate;

about 0.1% (wt/wt) of an unsaponifiable fraction of olive oil hydrolysate;

about 0.1% (wt/wt) bisabolol;

about 0.1% (wt/wt) of at least one of a hydrolyzed jojoba ester, a jojoba ester, and water;

about 2%-2.5% (wt/wt) of at least one of acrylamide, sodium acryloyldimethyl taurate copolymer, isohexadecane, and polysorbate 80;

about 0.6%-1% (wt/wt) of at least one of a jojoba ester, a hydrogenated jojoba oil, and tocopherol acetate;

up to about 0.06% (wt/wt) triethanolamine;

a fragrance; and

a preservative.

20. The composition of claim 13, wherein said emollient comprises at least one of a carrier particle and glycerin.

21. The composition of claim 13, further comprising an additive selected from the group consisting of:

a coloring agent, a dye, a color-shifting pigment, a preservative, a pH modifier, a weak base, a pH buffering agent, a thickening agent, a polymer, a fragrance, a polar extract of a fragrance, water, a polyacrylic acid, a sugar alcohol, glitter, a special effect pigment, a vitamin, a pro-vitamin, an amino acid, a protein, a peptide, a peptide complex, and an active agent.

22. The composition of claim 13, wherein said composition is formulated into at least one of a soap, a body wash, a stringent, a toner, a freshener, a gel, a towelette, a napkin, a feminine hygiene product, and a wipe.

23. The composition of claim 13, wherein said composition provides at least one of:

improvement of the function of the stratum corneum, reduction in transepidermal water loss, improved substantive feel, and improved moisturizing feel.

24. A method for managing dermatitic symptoms of mammalian integument, said method comprising the step of providing a moisturizing and sanitizing composition for topical application to the skin of a mammalian subject, said composition comprising:

an anti-microbial sanitizer having between about 60%-95% alcohol; and

an emollient comprising at least one of jojoba oil, a jojoba ester, hydrogenated jojoba oil, a jojoba hydrolysate, a hydrolyzed jojoba ester, a jojoba alcohol, an alkoxylated jojoba wax, an alkoxylated and at least partially hydrogenated jojoba wax, an alkoxylated product of jojoba oil interesterified with hydrogenated jojoba oil, and an isopropyl jojobate.

25. The method of claim 24, wherein said moisturizing and sanitizing composition further comprises glycerin.

26. The method of claim 24, wherein said dermatitic symptom comprises at least one of:

erythema, scaling, fissuring, xerosis, edema, vesiculation and lichenification.

27. The method of claim 24, wherein said composition provides at least one of:

improvement of the function of the stratum corneum, reduction in transepidermal water loss, improved substantive feel, and improved moisturizing feel.

28. A moisturizing hand sanitizer composition, said composition comprising an anti-microbial sanitizer and an emollient selected from the group consisting of jojoba oil, a jojoba ester, hydrogenated jojoba oil, a jojoba hydrolysate, a hydrolyzed jojoba ester, a jojoba alcohol, an alkoxylated jojoba wax, an alkoxylated and at least partially hydrogenated jojoba wax, an alkoxylated product of jojoba oil interesterified with hydrogenated jojoba oil, and an isopropyl jojobate.

29. The composition of claim 28, wherein said moisturizing hand sanitizer composition is certified as organic.