FORMULATIONS OF LIPOPHILIC BIOACTIVE MOLECULES
First Claim
1. A water-soluble formulation comprising a lipophilic bioactive molecule, a water-soluble reducing agent and a solubilizing agent having a structure according to Formula (IV):
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Abstract
This invention provides aqueous and non-aqueous clear formulations including at least one lipophilic bioactive molecules and an amphiphilic solubilizing agent. Exemplary aqueous formulations include a water-soluble reducing agent, which diminishes or prevents chemical degradation of the lipophilic bioactive molecule. The invention also provides methods of using the formulations of the invention. For example, the invention provides beverages including the formulations of the invention. The invention further provides methods of making the formulations and beverages.
71 Citations
89 Claims
- 1. A water-soluble formulation comprising a lipophilic bioactive molecule, a water-soluble reducing agent and a solubilizing agent having a structure according to Formula (IV):
- 27. A non-alcoholic beverage comprising solubilized ubiquinol, a water-soluble reducing agent and a solubilizing agent having a structure according to Formula (IV):
- 41. A non-alcoholic beverage comprising solubilized ubiquinone and a solubilizing agent, wherein said solubilizing agent is a member selected from polyoxyethanyl-tocopheryl-sebacate (PTS), polyoxyethanyl-sitosterol-sebacate (PSS), polyoxyethanyl-cholesterol-sebacate (PCS), polyoxyethanyl-ubiquinol-sebacate (PQS) and combinations thereof.
- 51. A process for making a water-soluble ubiquinol stock solution, said process comprising contacting an emulsion of ubiquinone in an aqueous medium with an amount of a water-soluble reducing agent sufficient to essentially quantitatively reduce said ubiquinone to ubiquinol, wherein said ubiquinone is solubilized in said emulsion using a solubilizing agent having a formula according to Formula (IV):
- 68. A process for the production of a non-alcoholic beverage, said process comprising forming an emulsion of ubiquinone in an aqueous medium using a solubilizing agent having a structure according to Formula (IV):
- 82. A method for chemically stabilizing a lipophilic bioactive molecule in an aqueous formulation, said method comprising contacting an emulsion of said molecule in an aqueous medium with an amount of a water-soluble reducing agent sufficient to prevent chemical degradation of said molecule, wherein said emulsion comprises a solubilizing agent having a formula according to Formula (IV):
Specification