SYSTEMS AND METHODS FOR DETECTING AND ANALYZING POLYMERS
First Claim
1. A detection system for analyzing a polymer, the detection system comprising:
- a first detection zone disposed in a first area of a microchannel and adapted to detect a polymer having first and second polymer portions to create a first detection signal when the polymer is in the first zone;
a second detection zone disposed in a second area of the microchannel that is different from the first area, the second detection zone adapted to detect the second polymer portion to create a second detection signal when the second portion is in the second area;
a data processor adapted to comparing the first and second detection signals and identify components that are not common to both the first and second detection signals.
0 Assignments
0 Petitions
Accused Products
Abstract
A detection system and methods for improving the ability of the detection system to recognize labels that are disposed on a polymer. Embodiments of the invention include schemes for selecting emitters and labels used within the system in a manner that allows an increase in the number of distinct labels that can be used together in a system. In other embodiments, the detection system and methods are directed to identifying portions of a detection signal that may be associated with extra labels residing within a detection zone. In other embodiments, the detection system and methods relate to using wide field imaging detectors while reducing out of focus noise contributions to detection signals of the system. Still, other embodiments relate to the use of linear array detectors to detect labels
-
Citations
26 Claims
-
1. A detection system for analyzing a polymer, the detection system comprising:
-
a first detection zone disposed in a first area of a microchannel and adapted to detect a polymer having first and second polymer portions to create a first detection signal when the polymer is in the first zone; a second detection zone disposed in a second area of the microchannel that is different from the first area, the second detection zone adapted to detect the second polymer portion to create a second detection signal when the second portion is in the second area; a data processor adapted to comparing the first and second detection signals and identify components that are not common to both the first and second detection signals. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
-
-
14. A method of analyzing a polymer in a detection system, the method comprising:
-
passing a plurality of polymers comprising a first polymer portion and a second polymer portion through a first detection zone to create a first detection signal, the first detection zone disposed in a first area of the microchannel; passing the second portion of polymers through a second detection zone to create a second detection signal, the second detection zone disposed in a second area of the microchannel; identifying components of the first detection signal that are associated with the second polymer portion by comparing the first detection signal with the second detection signal; and detecting components of the first detection signal associated with the second polymer portion to analyze the polymers. - View Dependent Claims (15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26)
-
Specification