Regulators of the hedgehog pathway, compositions and uses related thereto
1 Assignment
0 Petitions
Accused Products
Abstract
The present invention makes available, inter alia, methods and reagents for modulating smoothened-dependent pathway activation. In certain embodiments, the subject methods can be used to counteract the phenotypic effects of unwanted activation of a hedgehog pathway, such as resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function mutations.
-
Citations
69 Claims
-
1-42. -42. (canceled)
-
43. A veratrum-type alkaloid, wherein the veratrum-type alkaloid includes a nitrogen-containing ring comprising a tertiary amine having an extraannular substituent on the nitrogen,
wherein the extraannular substituent incorporates a substituted alkyl substituted with one or more groups selected from aryl, aralkyl, heteroaryl, heteroaralkyl, amide, acylamino, carbamate, urea, ketone, sulfonamide, carbocyclyl, heterocyclyl, polycyclyl, ether, halogen, alkenyl, and alkynyl.
- 47. A method for inhibiting mitotic cell proliferation in an animal comprising administering to the animal a veratrum-type alkaloid, wherein the veratrum-type alkaloid includes a nitrogen-containing ring comprising a tertiary amine having an extraannular substituent on the nitrogen.
- 53. A method for inhibiting activation of a hedgehog-patched pathway in a patient diagnosed with a hyperproliferative disorder comprising administering to the patient a veratrum-type alkaloid, wherein the veratrum-type alkaloid includes a nitrogen-containing ring comprising a tertiary amine having an extraannular substituent on the nitrogen.
- 59. A method for inhibiting unwanted hair growth or inhibiting spermatogenesis in a patient comprising administering to the patient a veratrum-type alkaloid, wherein the veratrum-type alkaloid includes a nitrogen-containing ring comprising a tertiary amine having an extraannular substituent on the nitrogen.
- 64. An in vitro method for inhibiting mitotic cell proliferation in a cell, comprising contacting the cell in vitro with a veratrum-type alkaloid, wherein the veratrum-type alkaloid includes a nitrogen-containing ring comprising a tertiary amine having an extraannular substituent on the nitrogen.
Specification