Triphenylethylene Compounds Useful as Selective Estrogen Receptor Modulators
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Abstract
Triphenylethylene compounds of formula (I) are provided. The compounds are particularly useful for selective estrogen receptor modulation.
57 Citations
18 Claims
- 1. A compound of Formula I
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7. A compound of Formula I
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8. A compound selected from:
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4,4′
-{2-[4-{[2-(dimethylamino)ethyl]oxy}-3-(methyloxy)phenyl]-1-butene-1,1-diyl}diphenol;4,4′
-{2-[4-{[2-(dimethylamino)ethyl]oxy}-3-(methyloxy)phenyl]-1-pentene-1,1-diyl}diphenol;4,4′
-{2-[4-{[2-(dimethylamino)ethyl]oxy}-3-(methyloxy)phenyl]-1-hexene-1,1-diyl}diphenol4,4′
-[2-(4-{[2-(1-pyrrolidinyl)ethyl]oxy}phenyl)-1-pentene-1,1-diyl]diphenol;4,4′
-[2-(4-{[2-(1-pyrrolidinyl)ethyl]oxy}phenyl)-1-hexene-1,1-diyl]diphenol;4,4′
-[2-(4-{[2-(1-piperidinyl)ethyl]oxy}phenyl)-1-pentene-1,1-diyl]diphenol;4,4′
-[2-(4-{[2-(1-pyrrolidinyl)ethyl]oxy}phenyl)-1-hexene-1,1-diyl]diphenol;4,4′
-[2-(4-{[2-(hexahydro-1H-azepin-1-yl)ethyl]oxy}phenyl)-1-pentene-1,1-diyl]diphenol; and4,4′
-[2-(4-{[2-(hexahydro-1H-azepin-1-yl)ethyl]oxy}phenyl)-1-hexene-1,1-diyl]diphenol,or a pharmaceutically acceptable salt or solvate thereof.
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10. (canceled)
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16. (canceled)
Specification