SYSTEM AND METHOD FOR DIAGNOSING AND TREATING LONG QT SYNDROME
First Claim
1. A system for diagnosing LQTS in a patient, comprising:
- electrodes for detecting an electrical systole, QT, in the patient;
at least one microphone for detecting a mechanical systole, QS2, in the patient;
a processing module receiving the detected electrical systole and the detected mechanical systole, calculating a QT/QS2 ratio, and outputting the ratio as a diagnostic result.
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Accused Products
Abstract
A system for diagnosing Long QT Syndrome (LQTS) derives a QT/QS2 ratio from an electrical systole (QT) and a mechanical systole (QS2) to detect a prolonged QT interval in a patient'"'"'s cardiac cycle. A processor acquires the systoles from a microphone and chest electrodes, calculates the QT/QS2 ratio, and outputs the result to a display. The processor may compare the QT/QS2 ratio to a threshold value stored in memory for diagnosing LQTS in the patient. A user interface provides for programming, set-up, and customizing the display. A mode selector allows the system to operate alternatively as a phonocardiograph, a 12 lead electrocardiograph, or a machine for diagnosing LQTS. A related method for diagnosing cardiac disorders such as LQTS includes measuring QT and QS2 during a same cardiac cycle, calculating a QT/QS2 ratio, and comparing the result to a threshold value derived from empirical data. The method may include measuring systoles both at rest and during exercise, and may be used for drug efficacy, dosage optimization, and acquired LQTS causality tests.
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Citations
42 Claims
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1. A system for diagnosing LQTS in a patient, comprising:
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electrodes for detecting an electrical systole, QT, in the patient; at least one microphone for detecting a mechanical systole, QS2, in the patient; a processing module receiving the detected electrical systole and the detected mechanical systole, calculating a QT/QS2 ratio, and outputting the ratio as a diagnostic result. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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18. A module for diagnosing LQTS in a patient, comprising:
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electrode inputs for receiving electrode signals; at least one microphone input for receiving an audio signal; a microprocessor receiving the electrode inputs and the at least one microphone input, deriving therefrom an electrical systole QT and a mechanical systole QS2, calculating a QT/QS2 ratio; and
outputting the ratio as a diagnostic result. - View Dependent Claims (19, 20, 21, 22)
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23. A method for diagnosing LQTS in a patient, comprising:
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measuring an electrical systole, QT, in the patient; measuring a mechanical systole, QS2, in the patient; calculating a QT/QS2 ratio; and displaying a result of the QT/QS2 calculation. - View Dependent Claims (24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36)
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37. A method for evaluating the effectiveness of a drug for treating LQTS in a patient, comprising:
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(a) measuring an electrical systole, QT, in the patient; (b) measuring a mechanical systole, QS2, in the patient; (c) calculating a QT/QS2 ratio; (d) recording a result of the calculated QT/QS2 ratio; administering a desired dose of the drug to the patient; and repeating steps (a) through (d). - View Dependent Claims (38)
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39. A method for optimizing a dosage of a drug for treating LQTS in a patient, comprising:
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(a) measuring an electrical systole, QT, in the patient; (b) measuring a mechanical systole, QS2, in the patient; (c) calculating a QT/QS2 ratio; (d) recording a result of the calculated QT/QS2 ratio; administering a dose of the drug to the patient; repeating steps (a) through (d); and comparing the recorded results to determine effectiveness of the dose. - View Dependent Claims (40)
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41. A method for evaluating whether a drug poses a risk of causing acquired LQTS in a patient, comprising:
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(a) measuring an electrical systole, QT, in the patient; (b) measuring a mechanical systole, QS2, in the patient; (c) calculating a QT/QS2 ratio; (d) recording a result of the calculated QT/QS2 ratio; administering a dose of the drug to the patient; repeating steps (a) through (d); and comparing the recorded results. - View Dependent Claims (42)
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Specification