Sensitizer Solutions, Systems, and Methods of Use

• US 20080255498A1
• Filed: 02/25/2008
• Published: 10/16/2008
• Est. Priority Date: 08/25/2005
• Status: Abandoned Application

• Current Assignee: OroScience, Inc.
• Original Assignee: OroScience, Inc.
• Inventors: Houle, Philip R.
• Application Number:
  US12/036,984
• Publication Number:
  US 20080255498A1
• Time in Patent Office: Days
• US Class Current: 604/20
• CPC Class Codes: A61C 17/0205 Container filling apparatus
• CPC Class Codes: A61C 17/0208 combined with means providing suction A61C17/0211 takes precedence
• CPC Class Codes: A61C 17/0211 specially adapted for rinsing the teeth of at least one jaw simultaneously A61C17/20 takes precedence
• CPC Class Codes: A61C 17/024 with constant liquid flow
• CPC Class Codes: A61C 17/028 with intermittent liquid flow
• CPC Class Codes: A61C 19/06 Implements for therapeutic treatment radiation therapy A61N5/00
• CPC Class Codes: A61C 19/063 Medicament applicators for teeth or gums, e.g. treatment with fluorides
• CPC Class Codes: A61K 41/00 Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
• CPC Class Codes: A61K 41/0057 Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
• CPC Class Codes: A61K 41/0071 PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
• CPC Class Codes: A61K 41/0076 PDT with expanded (metallo)porphyrins, i.e. having more than 20 ring atoms, e.g. texaphyrins, sapphyrins, hexaphyrins, pentaphyrins, porphocyanines
• CPC Class Codes: A61L 2/084 Visible light
• CPC Class Codes: A61L 2/085 Infrared radiation
• CPC Class Codes: A61L 2/10 Ultraviolet radiation
• CPC Class Codes: A61L 2/186 Peroxide solutions
• CPC Class Codes: A61L 2202/122 Chambers for sterilisation
• CPC Class Codes: A61L 2202/17 Combination with washing or cleaning means
• CPC Class Codes: A61N 2005/0604 Lungs and/or airways
• CPC Class Codes: A61N 5/0601 Apparatus for use inside the body
• CPC Class Codes: A61N 5/0603 for treatment of body cavities
• CPC Class Codes: A61N 5/062 : Photodynamic therapy, i.e. excitation of an agent
• CPC Class Codes: A61N 5/0624 : for eliminating microbes, germs, bacteria on or in the body

Abstract

A kit cleaning system and method is disclosed. One embodiment of the present invention has a photosensitizer solution supplied by a pressurized nozzle to the target site. Specific application of the solution is to an oral or skin surface target site. The photosensitizer solution is illuminated with sensitizing light creating reactive chemical species. Pressure and a solvent having an elevated concentration of oxygen or oxygen species improve the efficiency of the killing of pathogens. Methods of using the system within an oral cavity are also disclosed.

Claims

1. A treatment system comprising:

a delivery system configured to dispense a treatment solution at a treatment site, the dispensed treatment solution comprising a carrier including a sensitizer, a chemical species, and a solvent within which the chemical species is soluble; and

an activation device configured to deliver energy to the treatment solution at the treatment site, where the delivered energy is within a range appropriate to cause the sensitizer to promote the formation of a reactive chemical species from the chemical species.

2. The treatment system of claim 1 wherein the delivery system comprises a pressurized container.

3. The treatment system of claim 2 wherein the pressurized container is pressurized with ozone.

4. The treatment system of claim 1 wherein the sensitizer comprises toluidine blue.

5. The treatment system of claim 1 wherein the sensitizer comprises a photosensitizer and the activation device includes a light source.

6. The treatment system of claim 5 wherein the light source is configured to emit visible light.

7. The treatment system of claim 5 wherein the light source is configured to emit IR light.

8. The treatment system of claim 1 wherein the sensitizer comprises a sonosensitizer and the activation device includes an acoustic energy source.

9. The treatment system of claim 1 wherein the chemical species comprises molecular oxygen and the reactive chemical species comprises singlet oxygen.

10. The treatment system of claim 1 wherein the delivery system stores the sensitizer and the chemical species separately and is configured to mix the sensitizer and the chemical species to form the treatment solution.

11. The treatment system of claim 10 wherein the delivery system is configured to mix the sensitizer and the chemical species to form the treatment solution at the treatment site.

12. The treatment system of claim 10 wherein the delivery system is configured to mix the sensitizer and the chemical species to form the treatment solution before dispensing the treatment solution at the treatment site.

13. The treatment system of claim 1 wherein the carrier comprises water.

14. The treatment system of claim 1 wherein the carrier comprises a gel.

15. The treatment system of claim 1 wherein the carrier comprises a cream.

16. The treatment system of claim 1 wherein the solvent comprises a perfluorocarbon.

17. The treatment system of claim 1 wherein the solvent comprises perfluorodecalin.

18. The treatment system of claim 1 wherein the delivery system comprises an applicator.

19. The treatment system of claim 1 wherein the activation device is integral with the delivery system.

20. A treatment method comprising:

dispensing at a treatment site a treatment solution comprising a sensitizer, a chemical species, and a solvent within which the chemical species is soluble; and

forming a reactive chemical species by delivering energy to the treatment solution at the treatment site, where the delivered energy is within a range appropriate to cause the sensitizer to promote the formation of the reactive chemical species from the chemical species.

21. The treatment method of claim 20 wherein dispensing the treatment solution includes forming the treatment solution by mixing the sensitizer and the chemical species.

22. The treatment method of claim 21 wherein the mixing is performed at the treatment site.

23. The treatment method of claim 20 wherein delivering energy to the treatment solution at the treatment site includes delivering visible light to the treatment site.

24. The treatment method of claim 20 wherein delivering energy to the treatment solution at the treatment site includes delivering IR light to the treatment site.

25. The treatment method of claim 20 wherein delivering energy to the treatment solution at the treatment site includes delivering acoustic energy to the treatment site.

26. The treatment method of claim 20 wherein the treatment site comprises a non-biological surface.

27. The treatment method of claim 20 wherein the treatment site comprises a surface within an oral cavity.

28. The treatment method of claim 20 wherein the treatment site comprises diseased tissue.

29. The treatment method of claim 20 wherein the sensitizer is coupled to a targeting moiety characterized by an affinity to target such that the reactive chemical species is formed in proximity to the target.

30. The treatment method of claim 29 wherein the target comprises a microorganism.

31. The treatment method of claim 29 wherein the target comprises diseased tissue.