Surfaces differentially adhesive to bacteria and eukaryotic cells
First Claim
1. A surface coating, comprising:
- a primer coat that permits adhesion of eukaryotic cells thereto; and
a plurality of macromolecular structures attached to a surface of said primer coat and exposed at said surface, wherein each of said plurality of macromolecular structures has at least two submicron dimensions, and wherein at least some of said plurality of macromolecular structures have a cell-resistant character, said macromolecular structures having a cell-resistant character being sufficiently distributed across an area of said primer coat so as to permit adhesion of eukaryotic cells thereto and resist the adhesion of non-eukaryotic cells thereto.
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Accused Products
Abstract
A surface coating comprises a primer coat that permits adhesion of eukaryotic cells thereto, and a plurality of macromolecular structures attached to the primer coat. At least some of the macromolecular structures have a cell-resistant character, meaning that cells generally will not adhere to them. The macromolecular structures are distributed across an area of the primer coat so that the surface coating permits adhesion of the eukaryotic cells to the primer layer and resists the adhesion of non-eukaryotic cells. Typically, the primer coat comprises a self-assembled polymeric monolayer and the macromolecular structures comprise nanoscale hydrogels. Such surface coatings may be formed on articles of manufacture for insertion into the body, such as orthopedic devices.
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Citations
20 Claims
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1. A surface coating, comprising:
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a primer coat that permits adhesion of eukaryotic cells thereto; and a plurality of macromolecular structures attached to a surface of said primer coat and exposed at said surface, wherein each of said plurality of macromolecular structures has at least two submicron dimensions, and wherein at least some of said plurality of macromolecular structures have a cell-resistant character, said macromolecular structures having a cell-resistant character being sufficiently distributed across an area of said primer coat so as to permit adhesion of eukaryotic cells thereto and resist the adhesion of non-eukaryotic cells thereto. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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- 16. An article, at least a portion of said article being a substrate having a surface, said article having a surface coating comprising a primer coat that permits adhesion of eukaryotic cells thereto and has been formed on said surface of said substrate, and a plurality of macromolecular structures attached to a surface of said primer coat and exposed at said surface of said primer coat, wherein each of said plurality of macromolecular structures has at least two submicron dimensions, and wherein at least some of said plurality of macromolecular structures have a cell-resistant character, said macromolecular structures having a cell-resistant character being sufficiently distributed across an area of said primer coat so as to permit adhesion of eukaryotic cells thereto and resist the adhesion of non-eukaryotic cells thereto.
Specification