SUBSTANTIALLY NON-AQUEOUS FOAMABLE PETROLATUM BASED PHARMACEUTICAL AND COSMETIC COMPOSITIONS AND THEIR USES
First Claim
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1. A non-aqueous, non-alcoholic foamable composition comprising:
- a foamable carrier and at least one liquefied or compressed gas propellant, wherein the foamable carrier comprises;
(1) a petrolatum or mixtures thereof at a concentration of about 25% to about 95% by weight;
(2) a solvent substantially miscible in the petrolatum at a concentration of about 0% to about 70% by weight;
(3) at least one foam agent selected from the group consisting of a surfactant, a surfactant system, a foam adjuvant and combinations thereof;
at a concentration of about 0.1% to about 20% by weight;
wherein, in the absence of the solvent, the petrolatum is present in the foamable carrier at a concentration of at least about 50% by weight;
wherein, in the presence of the solvent;
(i) the petrolatum is present in the foamable carrier at a concentration of at least about 25% by weight and the solvent and petrolatum are together present in the foamable carrier at a concentration of least about 55% by weight;
or(ii) the amount of petrolatum is about the same as or in excess of the solvent and, together, the solvent and petrolatum are present in the foamable carrier at a concentration of at least about 80%;
wherein the ratio of the foamable carrier to the propellant is 100;
10 to 100;
35;
wherein the composition is substantially free of silicone; and
wherein the composition is stored in an aerosol container and upon release expands to form a breakable foam.
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Abstract
The present invention relates to stable substantially non-aqueous, non-alcoholic, non-silicone, foamable carrier compositions comprising petrolatum or mixtures thereof, at least one foam agent, at least one propellant, and with and without the addition of an active agent. The formulations may contain a solvent substantially miscible therein. The present invention further provides a method of treating, alleviating or preventing a disorder of mammalian subject in need thereof, comprising administering the above-mentioned compositions to an afflicted target site of said mammalian subject.
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Citations
41 Claims
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1. A non-aqueous, non-alcoholic foamable composition comprising:
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a foamable carrier and at least one liquefied or compressed gas propellant, wherein the foamable carrier comprises; (1) a petrolatum or mixtures thereof at a concentration of about 25% to about 95% by weight; (2) a solvent substantially miscible in the petrolatum at a concentration of about 0% to about 70% by weight; (3) at least one foam agent selected from the group consisting of a surfactant, a surfactant system, a foam adjuvant and combinations thereof;
at a concentration of about 0.1% to about 20% by weight;wherein, in the absence of the solvent, the petrolatum is present in the foamable carrier at a concentration of at least about 50% by weight; wherein, in the presence of the solvent; (i) the petrolatum is present in the foamable carrier at a concentration of at least about 25% by weight and the solvent and petrolatum are together present in the foamable carrier at a concentration of least about 55% by weight;
or(ii) the amount of petrolatum is about the same as or in excess of the solvent and, together, the solvent and petrolatum are present in the foamable carrier at a concentration of at least about 80%; wherein the ratio of the foamable carrier to the propellant is 100;
10 to 100;
35;wherein the composition is substantially free of silicone; and wherein the composition is stored in an aerosol container and upon release expands to form a breakable foam. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 25, 26, 27, 29, 30, 31, 32, 33, 34, 35, 38, 39)
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23. A non-aqueous, non-alcoholic foamable carrier composition comprising:
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a foamable carrier and at least one liquefied or compressed gas propellant, wherein the foamable carrier comprises; (1) a petrolatum or mixtures thereof at a concentration of about 50% to about 95% by weight; (2) a solvent substantially miscible in the petrolatum at a concentration of about 0% to about 45% by weight; (3) at least one foam agent selected from the group consisting of a surfactant, a surfactant system;
a foam adjuvant and combinations thereof at a concentration of about 0.1% to about 20% by weight; and(4) an effective amount of an active pharmaceutical agent; wherein the ratio of the foamable carrier to the propellant ranges from about 100;
10 to about 100;
35;wherein the composition is substantially free of silicone; and wherein the composition is resistant to centrifugation at 1000 rpm for about 10 minutes;
wherein the composition is flowable or flowable to a degree and or is shakable or substantially so when stored in an aerosol container and upon release expands to form a breakable foam having no substantial or sustained cooling affect and having a foam hardness in the range of about 5 g to about 100 g. - View Dependent Claims (24, 28, 36, 37)
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40. A low water content, non-alcoholic foamable composition comprising:
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a foamable carrier and at least one liquefied or compressed gas propellant, wherein the foamable carrier comprises; (1) a petrolatum or mixtures thereof at a concentration of about 25% to about 95% by weight; (2) a solvent substantially miscible in the petrolatum at a concentration of 0% to about 70% by weight; (3) at least one foam agent selected from the group consisting of a surfactant, a surfactant system, a foam adjuvant and combinations thereof;
at a concentration of about 0.1% to about 20% by weight; and(4) water at a concentration of up to about 26% by weight wherein, in the absence of the solvent, the petrolatum is present in the foamable carrier at a concentration of at least about 50% by weight; wherein, in the presence of the solvent; (i) the petrolatum is present in the foamable carrier at a concentration of at least about 25% by weight and the solvent and petrolatum are together present in the foamable carrier at a concentration of least about 55% by weight;
or(ii) the amount of petrolatum is about the same as or in excess of the solvent and, together, the solvent and petrolatum are present in the foamable carrier at a concentration of at least about 80%; wherein the ratio of the foamable carrier to the propellant ranges from about 100;
10 to about 100;
35;wherein the composition is substantially free of silicone; and wherein the composition is stored in an aerosol container and upon release expands to form a breakable foam.
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41. A low water content, non-alcoholic foamable carrier composition comprising:
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a foamable carrier and at least one liquefied or compressed gas propellant, wherein the foamable carrier comprises; (1) a petrolatum or mixtures thereof at a concentration of about 50% to about 95% by weight; (2) a solvent substantially miscible in the petrolatum at a concentration of about 0% to about 45% by weight; (3) at least one foam agent selected from the group consisting of a surfactant, a surfactant system;
a foam adjuvant and combinations thereof at a concentration of about 0.1% to about 20% by weight; and(4) an effective amount of an active pharmaceutical agent; wherein the solvent is water and is present in the carrier at a concentration of about 0.1% to about 26% by weight; wherein the ratio of the foamable carrier to the propellant ranges from about 100;
10 to about 100;
35;wherein the composition is substantially free of silicone; and wherein the composition is resistant to centrifugation at 1000 rpm for about 10 minutes;
wherein the composition is flowable or flowable to a degree and or is shakable or substantially so when stored in an aerosol container and upon release expands to form a breakable foam having no substantial or sustained cooling affect and having a foam hardness in the range of about 5 g to about 100 g.
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Specification