Hemostat

• US 20080260810A1
• Filed: 10/17/2005
• Published: 10/23/2008
• Est. Priority Date: 10/20/2004
• Status: Abandoned Application

• Current Assignee: Ethicon Incorporated (Johnson & Johnson), Omrix Biopharmaceuticals Incorporated (Johnson & Johnson)
• Original Assignee: Ethicon Incorporated (Johnson & Johnson), Omrix Biopharmaceuticals Incorporated (Johnson & Johnson)
• Inventors: Zhang, Guanghui, Martins, Sonia, Barone, Robin
• Application Number:
  US11/577,207
• Publication Number:
  US 20080260810A1
• Time in Patent Office: Days
• US Class Current: 424/447
• CPC Class Codes: A61F 13/01029 made of multiple layers
• CPC Class Codes: A61L 15/26 Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof A61L15/225 takes precedence
• CPC Class Codes: A61L 15/28 Polysaccharides or their derivatives A61L15/225 takes precedence
• CPC Class Codes: A61L 15/32 Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin A61L15/225 takes precedence
• CPC Class Codes: A61L 15/44 Medicaments
• CPC Class Codes: A61L 15/64 specially adapted to be resorbable inside the body
• CPC Class Codes: A61L 2300/418 Agents promoting blood coagulation, blood-clotting agents, embolising agents
• CPC Class Codes: A61L 2300/608 having two or more layers
• CPC Class Codes: A61L 2400/04 Materials for stopping bleeding
• CPC Class Codes: B32B 2250/20 All layers being fibrous or filamentary
• CPC Class Codes: B32B 2262/0276 Polyester fibres
• CPC Class Codes: B32B 2262/04 Cellulosic plastic fibres, e.g. rayon
• CPC Class Codes: B32B 2262/06 Vegetal fibres
• CPC Class Codes: B32B 2262/062 Cellulose fibres, e.g. cotton
• CPC Class Codes: B32B 23/02 in the form of fibres or filaments not used
• CPC Class Codes: B32B 23/10 next to a fibrous or filamentary layer
• CPC Class Codes: B32B 2307/726 Permeability to liquids, absorption
• CPC Class Codes: B32B 2556/00 Patches, e.g. medical patches, repair patches
• CPC Class Codes: B32B 27/36 comprising polyesters
• CPC Class Codes: B32B 5/022 Non-woven fabric
• CPC Class Codes: B32B 5/024 : Woven fabric
• CPC Class Codes: B32B 5/026 : Knitted fabric
• CPC Class Codes: B32B 5/26 : another layer next to it also being fibrous or filamentary relative arrangement of fibres or filaments of different layers B32B5/12
• CPC Class Codes: C08L 67/04 : Polyesters derived from hydroxycarboxylic acids, e.g. lactones C08L67/06 takes precedence
• CPC Class Codes: Y10T 442/2525 : Coating or impregnation functions biologically [e.g., insect repellent, antiseptic, insecticide, bactericide, etc.]

Abstract

The present invention is directed towards a hemostat comprising an absorbable foam, an absorbable woven or knitted fabric, thrombin and/or fibrinogen.

Claims

1. A hemostat comprising an absorbable foam, an absorbable woven or knitted fabric, thrombin and fibrinogen.

2. The hemostat of claim 1, where the foam comprises one or more polymers selected from the group consisting of polysaccharides, albumin, chitin, carboxymethyl chitin, hyaluronic acid, salts of hyaluronic acid, alginate, alginic acid, propylene glycol alginate, glycogen, dextran, dextran sulfate, curdlan, pectin, pullulan, xanthan, chondroitin, chondroitin sulfates, carboxymethyl dextran, carboxymethyl chitosan, chitosan, heparin, heparin sulfate, heparan, heparan sulfate, dermatan sulfate, keratan sulfate, carrageenans, chitosan, starch, amylose, amylopectin, poly-N-glucosamine, polymannuronic acid, polyglucuronic acid polyguluronic acid, and derivatives of any of the above.

3. The hemostat of claim 2, where the foam comprises a polysaccharide selected from the group consisting of methylcellulose, alkylhydroxyalkyl cellulose, hydroxyalkyl cellulose, cellulose sulfate, salts of carboxymethyl cellulose, carboxymethyl cellulose, carboxyethyl cellulose.

4. The hemostat of claim 3, where the absorbable woven or knitted fabric comprises oxidized polysaccharides.

5. The hemostat of claim 4, where the absorbable woven or knitted fabric comprises oxidized cellulose.

6. The hemostat of claim 5, where the absorbable woven or knitted fabric comprises oxidized regenerated cellulose.

7. The hemostat of claim 5, where the absorbable woven or knitted fabric is an absorbable knitted fabric comprising oxidized regenerated cellulose.

8. The hemostat of claim 1, where the foam comprises carboxymethyl cellulose and albumin, the absorbable woven or knitted fabric comprises oxidized regenerated cellulose, and the thrombin and fibrinogen are incorporated into or sprayed onto the foam.

9. The hemostat of claim 8, where the weight ratio of carboxymethyl cellulose to the albumin ranges from about 1:

8 to 8;

1 by weight.

10. The hemostat of claim 8, wherein the thrombin activity on the hemostat ranges from about 20 to 500 IU/cm², and the fibrinogen activity ranges from about 2 to 15 mg/cm².