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Oral dosage formulations of protease-resistant polypeptides

  • US 20080260820A1
  • Filed: 04/19/2007
  • Published: 10/23/2008
  • Est. Priority Date: 04/19/2007
  • Status: Abandoned Application
First Claim
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1. A dosage formulation, comprising an amount of a therapeutic polypeptide sufficient, upon oral administration to a subject, to reach therapeutically effective levels in the bloodstream in the subject, wherein:

  • the therapeutic protein is modified in its primary sequence of amino acids, whereby it is more protease resistant than in the absence of the modifications, and the protein can reach therapeutically effective levels in the bloodstream upon oral administration; and

    the amount is about or is 10-100 times the subcutaneous dose for the same indication and for the same therapeutic polypeptide that is not modified to be protease resistant.

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