SUSTAINED RELEASE INTRAOCULAR IMPLANTS AND METHODS FOR PREVENTING RETINAL DYSFUNCTION
First Claim
1. A method for enhancing normal retinal neuronal function comprising the step of intravitreal administration of an ophthalmic composition comprising microspheres of an alpha-2 adrenergic receptor agonist associated with a biodegradable polymer matrix.
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Accused Products
Abstract
Biocompatible intraocular microspheres and implants include an alpha-2 adrenergic receptor agonist and a polymer associated with the alpha-2 adrenergic receptor agonist to facilitate release of the alpha-2 adrenergic receptor agonist into an eye for an extended period of time. The alpha-2 adrenergic receptor agonist may be associated with a biodegradable polymer matrix, such as a matrix of a two biodegradable polymers. The implants may be placed in an eye to treat or to prevent the occurrence of one or more ocular conditions, to reduce one or more symptoms of an ocular condition, such as an ocular neurosensory disorder and the like, to enhance normal retinal function and/or to lower intraocular pressure.
135 Citations
7 Claims
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1. A method for enhancing normal retinal neuronal function comprising the step of intravitreal administration of an ophthalmic composition comprising microspheres of an alpha-2 adrenergic receptor agonist associated with a biodegradable polymer matrix.
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2. A method for reducing intraocular pressure comprising the step of intravitreal administration of an ophthalmic composition comprising microspheres of an alpha-2 adrenergic receptor agonist associated with a biodegradable polymer matrix.
- 3. A method of treating a retinal dysfunction in an eye of a patient, comprising the step of intravitreal administration of biodegradable intraocular microspheres, the microspheres comprising an alpha-2 adrenergic receptor agonist associated with a biodegradable polymer matrix that releases alpha-2 adrenergic receptor effective to prevent or reduce a symptom of a retinal dysfunction.
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7. A method for enhancing normal retinal neuronal function and reducing intraocular pressure without significantly obscuring vision, the method comprising the step of intravitreal administration of an ophthalmic composition comprising microspheres of a brimonidine associated with a biodegradable polylactide polyglycolide copolymer polymer matrix.
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