Analyte Sensors and Compositions for Use Therein
First Claim
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1. An analyte sensor suitable for implantation in a patient comprising:
- an electrode surface comprising an enzyme; and
a biocompatible analyte permeable composition comprising a nitric oxide generating agent, wherein said composition generates nitric oxide when in contact with nitrosothiols.
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Abstract
The present invention relates to analyte sensors and compositions, membranes for use in analyte sensors. For example, an analyte sensor is provided that comprise an electrode surface comprising an enzyme; an a biocompatible analyte permeable composition comprising a nitric oxide generating agent.
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Citations
29 Claims
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1. An analyte sensor suitable for implantation in a patient comprising:
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an electrode surface comprising an enzyme; and a biocompatible analyte permeable composition comprising a nitric oxide generating agent, wherein said composition generates nitric oxide when in contact with nitrosothiols. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
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- 23. A biocompatible membrane for use in an analyte sensor comprising a nitric oxide generating agent, wherein said analyte sensor is capable of continuously measuring blood glucose levels for 3 days or more.
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26. An analyte sensor comprising:
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an electrode surface comprising an enzyme; an analyte permeable composition; and a biocompatible composition comprising a nitric oxide generating agent, wherein said composition generates nitric oxide when in contact with nitrosothiols
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27. A method for detecting glucose levels in the blood of a patient over 2 days or more, wherein said method comprises:
instilling a glucose sensor that comprises a biocompatible analyte permeable composition subcutaneously into a patient;
wherein said composition comprises a nitric oxide generating agent.
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28. A glucose detection kit comprising
a glucose sensor comprising a nitric oxide generating agent; - and
instructions for use.
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29. The use of a nitric oxide generating agent for a blood glucose sensor.
Specification