Ultrasound Apparatus and Method to Treat an Ischemic Stroke

• US 20080262350A1
• Filed: 03/15/2006
• Published: 10/23/2008
• Est. Priority Date: 11/18/2005
• Status: Abandoned Application

• Current Assignee: Cerevast Therapeutics, Inc.
• Original Assignee: Imarx Therapeutics, Inc. (Sycamore Entertainment Group, Inc.)
• Inventors: Unger, Evan C.
• Application Number:
  US12/094,263
• Publication Number:
  US 20080262350A1
• Time in Patent Office: Days
• US Class Current: 600/439
• CPC Class Codes: A61B 2090/502 Headgear, e.g. helmet, spectacles
• CPC Class Codes: A61B 5/4076 Diagnosing or monitoring particular conditions of the nervous system A61B5/4821, A61B5/4824 take precedence
• CPC Class Codes: A61B 5/6814 Head
• CPC Class Codes: A61B 8/0816 using echo-encephalography
• CPC Class Codes: A61B 8/0833 involving detecting or locating foreign bodies or organic structures
• CPC Class Codes: A61B 8/14 Echo-tomography
• CPC Class Codes: A61B 8/4227 characterised by straps, belts, cuffs or braces
• CPC Class Codes: A61B 8/4281 characterised by sound-transmitting media or devices for coupling the transducer to the tissue
• CPC Class Codes: A61B 8/4472 Wireless probes
• CPC Class Codes: A61B 8/4483 characterised by features of the ultrasound transducer
• CPC Class Codes: A61B 8/481 involving the use of contrast agent, e.g. microbubbles introduced into the bloodstream analysis of echo signal exploiting properties of a contrast enhancer in devices for short-range imaging with acoustic waves G01S7/52039
• CPC Class Codes: A61B 8/546 involving monitoring or regulation of device temperature
• CPC Class Codes: A61N 2007/0078 with multiple treatment transducers
• CPC Class Codes: A61N 7/02 Localised ultrasound hyperthermia hyperthermia in general A61F7/00

Abstract

An apparatus and a method are disclosed to treat a patient sustaining cerebral ischemia or an ischemic stroke in the brain. The method supplies an ultrasound emitting device 100 comprising a plurality of ultrasound transducers (180) and emitting first ultrasound energy by the ultrasound emitting device, where that first ultrasound energy comprises first power. The method locates using the first ultrasound energy an occlusion disposed in one of the patient'"'"'s cerebral blood vessels. The method then emits second ultrasound energy by the ultrasound emitting device, where that second ultrasound energy comprises second power, where the second power is greater than said first power. The method lyses the occlusion using the second ultrasound energy.

Claims

1. A method for treating a patient sustaining cerebral ischemia or an ischemic stroke in the brain, comprising the steps of:

supplying an ultrasound emitting device comprising a plurality of ultrasound transducers;

emitting first ultrasound energy by said ultrasound emitting device, wherein said first ultrasound energy comprises first power;

locating using said first ultrasound energy an occlusion disposed in one of said patient'"'"'s cerebral blood vessels,

emitting second ultrasound energy by said ultrasound emitting device, wherein said second ultrasound energy comprises second power, wherein said second power is greater than said first power;

lysing said occlusion using said second ultrasound energy.

2. The method of claim 1, wherein said supplying an ultrasound emitting device step further comprises supplying an ultrasound emitting device comprising (N) therapeutic ultrasound transducers capable of emitting said second ultrasound energy, wherein (N) is greater than 1, said method further comprising the steps of:

supplying a controller interconnected with each of said (N) ultrasound transducers;

providing by said controller the (i)th signal to the (i)th therapeutic ultrasound transducer, wherein (i) is greater than or equal to 1 and less than or equal to (N);

wherein said emitting second ultrasound energy step further comprises emitting by the (i)th therapeutic ultrasound transducer the (i)th second ultrasound energy comprising the (i)th frequency and the (i)th phase.

3. The method of claim 2, further comprising the steps of:

establishing (N) therapeutic insonation regimes, wherein the (i)th therapeutic insonation regime comprises the (i)th frequency pattern and the (i)th phase pattern;

wherein said supplying a controller step further comprises supplying a controller comprising a processor and memory;

encoding said (N) therapeutic insonation regimes in said memory;

using by said processor the (i)th therapeutic insonation regime to generate said (i)th signal.

4. The method of claim 3, wherein said supplying an ultrasound emitting device further comprises supplying an ultrasound emitting device comprising said controller.

5. The method of claim 4, further comprising the steps of:

supplying a computing device;

wherein said establishing (N) therapeutic insonation regimes is performed using said computing device;

downloading said (N) therapeutic insonation regimes from said computing device to said memory.

6. The method of claim 3, wherein the (i)th frequency pattern differs from the frequency pattern associated each of the remaining (N−

1) therapeutic insonation regimes.

7. The method of claim 3, wherein the (i)th phase pattern differs from the phase pattern associated each of the remaining (N−

1) therapeutic insonation regimes.

8. The method of claim 1, wherein said supplying an ultrasound emitting device step further comprises supplying an ultrasound emitting device comprising a diagnostic ultrasound transducer capable of emitting said first ultrasound energy, a receiver to detect reflected ultrasound energy;

supplying a controller interconnected with said diagnostic ultrasound transducer and said receiver;

supplying a visual display device interconnected with said controller;

receiving reflected first ultrasound energy;

generating by said controller an image of the tissue structure underlying said diagnostic ultrasound transceiver;

displaying said image on said visual display device.

9. The method of claim 8, further comprising the steps of:

establishing an imaging regime;

wherein said supplying a controller step further comprises supplying a controller comprising a processor and memory;

encoding said imaging regime in said memory;

using by said processor said imaging regime to cause said diagnostic ultrasound transducer to emit said first ultrasound energy.

10. The method of claim 9, wherein said establishing an imaging regime, further comprises establishing an imaging regime selected from the group consisting of harmonic imaging, pulse inversion imaging, pulse inversion imaging using a low mechanical index, pulse inversion imaging in combination with Doppler detection, and power modulation imaging.

11. The method of claim 8, wherein said supplying an ultrasound emitting device further comprises supplying an ultrasound emitting device comprising said controller.

12. The method of claim 11, wherein said supplying an ultrasound emitting device further comprises supplying an ultrasound emitting device comprising said visual display device.

13. The method of claim 11, further comprising the steps of:

supplying a computing device;

wherein said establishing an imaging regime is performed using said computing device;

downloading said imaging regime from said computing device to said memory.

14. The method of claim 8, further comprising the steps of:

providing a mixture comprising a plurality of gas-filled microbubbles;

providing a therapeutically effective amount of said mixture in said occluded cerebral vessel;

detecting said gas-filled microbubbles adjacent said occlusion prior to emitting said second ultrasound energy.

15. The method of claim 14, wherein said detecting gas-filled microbubbles step further comprises:

establishing a threshold quantity of microbubbles;

determining if the detected microbubbles adjacent said occlusion exceed said threshold quantity;

operative if the detected microbubbles adjacent said occlusion exceed said threshold quantity, emitting said second ultrasound energy.

16. An article of manufacture comprising at least one diagnostic ultrasound transducer to emit first ultrasound energy comprising first power, (N) therapeutic ultrasound transducers to emit second ultrasound energy comprising second power, and a computer readable medium having computer readable program code disposed therein to operate said article of manufacture, wherein (N) is greater than or equal to 1, and wherein said second power is greater than said first power, the computer readable program code comprising a series of computer readable program steps to effect:

providing the (i)th signal to the (i)th therapeutic ultrasound transducer, wherein (i) is greater than or equal to 1 and less than or equal to (N);

emitting by said (i)th therapeutic ultrasound transducer second ultrasound energy comprising the (i)th frequency and the (i)th phase.

17. The article of manufacture of claim 16, wherein said article of manufacture further comprises memory and (N) therapeutic insonation regimes encoded in said memory, wherein the (i)th therapeutic insonation regime comprises the (i)th frequency pattern and the (i)th phase pattern, and wherein, for each value of (i), the (i)th frequency pattern differs from the frequency pattern comprised by each of the remaining (N−

1) therapeutic insonation regimes.

18. The article of manufacture of claim 17, wherein, for each value of (i), the (i)th phase pattern differs from the phase pattern comprised by each of the remaining (N−

1) therapeutic insonation regimes.

19. The article of manufacture of claim 18, further comprising a receiver to detect reflected first ultrasound energy and a visual display device, said computer readable program code further comprising a series of computer readable program steps to effect:

emitting first ultrasound energy;

receiving reflected first ultrasound energy;

generating an image of the tissue structure underlying said diagnostic ultrasound transducer;

displaying on said visual display said device.

20. The article of manufacture of claim 19, wherein said article of manufacture further comprises a threshold quantity of microbubbles, said computer readable program code further comprising a series of computer readable program steps to effect:

detecting gas-filled microbubbles adjacent an occlusion in a blood vessel;

determining if the detected microbubbles adjacent said occlusion exceed said threshold quantity;

operative if the detected microbubbles adjacent said occlusion exceed said threshold quantity, emitting said second ultrasound energy.