Microneedle Arrays and Methods of Preparing Same
First Claim
1. A drug delivery device comprising:
- a microneedle array comprising a substrate and a plurality of microneedles extending out from the substrate; and
a multi-phase matrix coating containing an active substance on at least a portion of the microneedle surface;
wherein the multi-phase matrix coating comprises a first solid phase and a liquid phase, andwherein the first solid phase comprises a water-soluble polymer.
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Abstract
A microneedle array having a substrate and a plurality of microneedles extending out from the substrate with a multi-phase matrix coating on at least a portion of the microneedle surface of the microneedle array. The multi-phase matrix coating comprises an active substance and has a first solid phase and a liquid phase. The first solid phase comprises a water-soluble polymer. Also, a method of providing an active substance- containing matrix coating on a microneedle array in which a water-soluble polymer is applied to the microneedle surface of the array to form a dried coating of water-soluble polymer. A coating solution comprising an active substance, a liquid capable of phase separating from the water-soluble polymer, and a carrier fluid is prepared and applied to the dried coating of water-soluble polymer. At least a portion of the carrier fluid is removed from the array.
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Citations
21 Claims
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1. A drug delivery device comprising:
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a microneedle array comprising a substrate and a plurality of microneedles extending out from the substrate; and a multi-phase matrix coating containing an active substance on at least a portion of the microneedle surface; wherein the multi-phase matrix coating comprises a first solid phase and a liquid phase, and wherein the first solid phase comprises a water-soluble polymer. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. (canceled)
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14. A method of preparing a drug delivery device comprising the steps of:
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a) providing a microneedle array having a substrate and a plurality of microneedles extending out from the substrate; b) applying a water-soluble polymer to the microneedle surface to form a dried coating of water-soluble polymer on at least a portion of the microneedles; c) preparing a coating solution comprising an active substance, a liquid capable of phase separating from the water-soluble polymer, and a carrier fluid; d) applying the coating solution to the dried coating of water-soluble polymer; and e) removing at least a portion of the carrier fluid from the array, thereby providing an active substance-containing matrix coating on the microneedle array. - View Dependent Claims (15, 16, 17, 18, 19, 20, 21)
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Specification