POLYMERS CONTAINING SILOXANE MONOMERS
First Claim
1. A biocompatible polymer comprising siloxane monomers that impart flexibility to the polymer and monomers that impart mechanical strength to the polymer, wherein the polymer has_the structure of formula I:
- wherein m and n are independently positive integers, wherein X is an absence, or a linking group, and wherein A is a biobeneficial moiety, wherein the siloxane monomer is derived from a compound having the formula of where R1 and R2 are independently H, F, Cl, Br, I, C1-C10 alkyl, C3-C10 cycloalkyl, substituted C1-C10 alkyl, haloalkyl, fluoroalkyl, chloroalkyl, bromoalkyl, iodoalkyl, phenyl, substituted phenyl, alkoxyphenyl, halophenyl and alkylphenyl, aryl, or substituted aryl, alkoxyaryl, haloaryl and alkylaryl, and Z1 and Z2 are independently absence or oxygen (O).
1 Assignment
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Accused Products
Abstract
A polymer of siloxanes as flexibility monomers and strength monomers is provided. It is also provided a polymer blend that contains a polymer formed of siloxane monomers and strength monomers and another biocompatible polymer. The biocompatible polymer or polymer blend described herein and optionally a bioactive agent can form a coating on an implantable device such as a drug-delivery stent. The implantable device can be used for treating or preventing a disorder such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, or combinations thereof.
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Citations
16 Claims
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1. A biocompatible polymer comprising siloxane monomers that impart flexibility to the polymer and monomers that impart mechanical strength to the polymer, wherein the polymer has_the structure of formula I:
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wherein m and n are independently positive integers, wherein X is an absence, or a linking group, and wherein A is a biobeneficial moiety, wherein the siloxane monomer is derived from a compound having the formula of where R1 and R2 are independently H, F, Cl, Br, I, C1-C10 alkyl, C3-C10 cycloalkyl, substituted C1-C10 alkyl, haloalkyl, fluoroalkyl, chloroalkyl, bromoalkyl, iodoalkyl, phenyl, substituted phenyl, alkoxyphenyl, halophenyl and alkylphenyl, aryl, or substituted aryl, alkoxyaryl, haloaryl and alkylaryl, and Z1 and Z2 are independently absence or oxygen (O). - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
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Specification