MASS SPECTROMETER ION GUIDE PROVIDING AXIAL FIELD, AND METHOD

• US 20080265154A1
• Filed: 04/30/2007
• Published: 10/30/2008
• Est. Priority Date: 04/30/2007
• Status: Active Grant

• Current Assignee: PerkinElmer Scientific Canada ULC
• Original Assignee: Ionics Mass Spectrometry Group Inc.
• Inventors: Cousins, Lisa, Tomski, Ilia, Javahery, Gholamreza
• Granted Patent: US 7,868,289 B2
• Time in Patent Office: Days
• US Class Current: 250/288
• CPC Class Codes: H01J 49/063 Multipole ion guides, e.g. quadrupoles, hexapoles

Abstract

An ion guide includes a plurality of rods, arranged about an axis that extends lengthwise from one end to the other of the guide. The rods guide ions in a guide region along and about the axis. A conductive casing surrounds the rods. The casing and the rods are geometrically arranged to produce an axial electric field along the axis. Specifically, the geometry is such that a first constant applied DC voltage (U_DC), applied to the rods, and a second constant applied DC voltage (U_CASE) applied to the casing, produce a voltage gradient between said casing and said axis that has a different magnitude at different positions along said axis.

Claims

1. An ion guide comprising:

a plurality of rods, arranged in multipole about an axis that extends lengthwise from a first end to a second end of said ion guide, to guide ions in a guide region along and about said axis;

wherein each of said plurality of rods is closer to said axis proximate said first end of said ion guide than said axis proximate said second end of said ion guide;

a conductive casing surrounding said plurality of rods;

at least one voltage source, interconnected to said plurality of rods and to said casing to produce a voltage gradient between said casing and said axis, said voltage gradient having a different magnitude at different positions along said axis to produce an axial electric field along said axis.

2. The ion guide of claim 1, wherein said at least one voltage source provides a time varying voltage to said conductive casing to produce said field.

3. The ion guide of claim 1, wherein said at least one voltage source provides a DC voltage to said conductive casing to produce said field.

4. The ion guide of claim 1, wherein each of said rods comprises a plurality of rod segments.

5. An ion guide comprising:

a plurality of rods, arranged about an axis that extends lengthwise from a first end to a second end of said ion guide, to guide ions in a guide region along and about said axis;

a conductive casing surrounding said plurality of rods;

wherein said casing and said plurality of rods are geometrically arranged so that a first constant applied DC voltage (U_DC) applied to said rods, and a second constant applied DC voltage (U_CASE) applied to said conductive casing, produce a voltage gradient between said casing and said axis that has a different magnitude at different positions along said axis, to produce an axial electric field along said axis.

6. The ion guide of claim 5, wherein said conductive casing is cylindrical and wherein each of said plurality of rods is closer to said axis proximate said second end of said ion guide than said axis proximate said first end of said ion guide.

7. The ion guide of claim 5, wherein said conductive casing is cylindrical and wherein the spacing between adjacent ones of said plurality of rods is closer proximate said second end of said ion guide than proximate said first end of said ion guide.

8. The ion guide of claim 5, wherein said conductive casing is frustro-conical, and wherein all of said plurality of rods are parallel to said axis.

9. The ion guide of claim 5, wherein said conductive casing is formed as a truncated cone, and wherein said plurality of rods are parallel to each other.

10. The ion guide of claim 5, where said conductive casing is cylindrical and wherein each of said plurality of rods is tapered in cross section along said axis, with a larger cross section proximate said second end of said ion guide and a smaller cross section proximate said second end of said ion guide.

11. The ion guide of claim 10, maintained at a pressure between about 10⁻

4 and 10<sup>−

2</sup> Torr.

12. The ion guide of claim 10, maintained at a pressure between about 10⁻

4 and 10 Torr.

13. The ion guide of claim 5, wherein four rods are arranged in quadrupole about said axis.

14. The ion guide of claim 5, wherein six rods are arranged in hexapole about said axis.

15. The ion guide of claim 5, wherein said rods have generally round cross-sections.

16. The ion guide of claim 5, wherein said rods have generally rectangular cross-sections.

17. The ion guide of claim 15, wherein said rods are formed as shims.

18. The ion guide of claim 5, wherein said rods have generally oval cross-sections.

19. The ion guide of claim 5, wherein said conductive casing has a conductive inner surface.

20. The ion guide of claim 5, wherein said casing comprises a focusing lens at each end, to allow said ion guide to function as a collision cell.

21. The ion guide of claim 5, wherein eight rods are arranged in octopole about said axis

22. The ion guide of claim 5, wherein each of said plurality of rods has a circular cross section, and wherein the ratio of the diameter of said rods the diameter of a circumscribed circle remains constant along said length.

23. The ion guide of claim 5, wherein each of said conductive said rods includes a tapered slot extending generally parallel to said axis and widening along said axis.

24. The ion guide of claim 5, wherein said conductive casing is cylindrical and wherein each of said plurality of rods is formed as a lengthwise extending cylindrical segment, each cylindrical segment subtending an angle about said axis, and including a tapered slot widening along said axis.

25. A mass spectrometer comprising the ion guide of claim 5.

26. A method comprising:

providing a plurality of rods about an axis that extends lengthwise from a first end to a second end to guide ions in a guide region along and about said axis;

providing a conductive casing surrounding said plurality of rods creating a multipolar electric field between said plurality of rods to contain ions in said guide region,

applying a substantially DC voltage to said conductive casing and said rods,

wherein said casing and said plurality of rods are geometrically arranged so that said substantially DC voltage to said casing and said rods, produce a voltage gradient between said casing and said axis that has a different magnitude at different positions along said axis, to produce an axial electric field along said axis.

27. The method of claim 26, wherein said providing comprises providing four rods about said axis.

28. The method of claim 26, wherein each of said rods is tilted at an angle a relative to said axis.

29. The method of claim 26, wherein said creating a multipolar electric field between said plurality of rods comprises applying a sinusoidal voltage across opposite ones of said plurality of rods.

30. The method of claim 26, further comprising adjusting said substantially DC voltage applied to said rods and said casing, in dependence on ions to be guided by said rods, in order to assist in fragmentation of said ions between said rods.

31. The method of claim 26, wherein said at least one voltage source applies a different DC voltages to different rod segments forming one of said rods.