Oral Care Composition To Reduce Or Eliminate Dental Sensitivity

• US 20080267891A1
• Filed: 04/16/2008
• Published: 10/30/2008
• Est. Priority Date: 04/30/2007
• Status: Abandoned Application

• Current Assignee: Colgate-Palmolive Company
• Original Assignee: Colgate-Palmolive Company
• Inventors: Prencipe, Michael, Wang, Qin, Christopoulou, Constantina, Chopra, Suman K., Zaidel, Lynette
• Application Number:
  US12/103,919
• Publication Number:
  US 20080267891A1
• Time in Patent Office: Days
• US Class Current: 424/50
• CPC Class Codes: A61K 2800/412 Microsized, i.e. having sizes between 0.1 and 100 microns
• CPC Class Codes: A61K 8/04 Dispersions; Emulsions
• CPC Class Codes: A61K 8/25 Silicon; Compounds thereof
• CPC Class Codes: A61K 8/8164 Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a carboxyl radical, and containing at least one other carboxyl radical in the molecule, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers, e.g. poly (methyl vinyl ether-co-maleic anhydride)
• CPC Class Codes: A61Q 11/00 Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Abstract

The invention includes an oral care composition that reduces and/or eliminates the perception of tooth sensitivity. The composition includes an adherent material and particles having an average particle size of about 8 microns or less. The particles are present in the composition in an amount of about 5% by weight. Also included within the scope of the invention are related methods, such as methods of occluding a dentin tubule.

Claims

1. An oral care composition comprising:

a. an adherent material;

b. particles having an average particle size of about 8 microns or less, wherein the particles are present in the composition in an amount of about 5% by weight or greater, and the composition provides a fluid flow rate of no greater than about 45% of the fluid flow rate of etched dentin.

2. The composition of claim 1, wherein the particles have a porosity of less than about 0.45 cc/g in pores of about 600 Angstroms or smaller.

3. The composition of claim 1, wherein adherent material is a polymer having a number average molecular weight of about 1,000 to about 5,000.

4. The composition of claim 1, wherein the adherent material is selected from polymers of polyvinyl phosphonic acid, poly(1-phosphonopropene) sulfonic acid, poly(beta styrene phosphonic acid), alpha styrene phosphonic acid, synthetic anionic polymeric polycarboxylate, maleic anhydride, maleic acid, and methyl vinyl ether.

5. The composition of claim 1, wherein the adherent molecule is a polymer of methyl vinyl ether and maleic anhydride.

6. The composition of claim 1, wherein the particle has an average particle size of about 1 to about 5 microns.

7. The composition of claim 1, wherein the particle has an average particle size of less than about 7 microns.

8. The composition of claim 1, wherein the composition is formulated into a form selected from a rinse, a paste, a gel, a gum, a dissolvable lozenge, and a film.

9. The composition of claim 8, wherein the film is a dissolvable film.

10. The composition of claim 1 further comprising a desensitizing agent.

11. The composition of claim 1 further comprising a desensitizing agent selected from a nitrate salt, an arginine ester, a bicarbonate salt, potassium nitrate, and an arginine-bicarbonate-phytate complex.

12. The composition of claim 1 further comprising an antibacterial agent.

13. The composition of claim 1 further comprising an agent selected from a chemical whitening agent, an opaque whitening agent and an anticalculus agent.

14. The composition of claim 1 further comprising triclosan.

15. The composition of claim 1 further comprising a surfactant system that comprises sodium lauryl sulfate and tauranol.

16. The composition of claim 1 further comprising a surfactant system that consists essentially of sodium lauryl sulfate and tauranol in a ratio of about 1:

5 to about 1;

3.

17. The composition of claim 1 further comprising an agent selected from a stannous ion agent;

chlorhexidine;

alexidine;

hexetidine;

sanguinarine;

benzalkonium chloride;

salicylanilide;

domiphen bromide;

cetylpyridinium chloride (CPC);

tetradecylpyridinium chloride (TPC);

N-tetradecyl-4-ethylpyridinium chloride (TDEPC);

octenidine;

delmopinol;

octapinol;

nisin;

zinc ion agent;

copper ion agent;

essential oils;

furanones;

bacteriocins, ethyl lauroyl arginate, extracts of magnolia, a metal ion source, arginine bicarbonate, honokiol, magonol, ursolic acid, ursic acid, morin, extract of sea buckthorn, a peroxide, an enzyme, a Camellia extract, a flavonoid, a flavan, halogenated diphenyl ether, creatine, and propolis.

26. The composition of claim 2 further comprising triclosan.

18. A method of reducing dental sensitivity comprising applying to the surface of a mammalian tooth a composition comprising an adherent material and a silica particle having an average particle size of about 8 microns or less, wherein the particles are present in the composition in an amount of about 5% by weight or greater.

19. The method of claim 18, wherein the adherent material is selected from polymers of polyvinyl phosphonic acid, poly(1-phosphonopropene) sulfonic acid, poly(beta styrene phosphonic acid), alpha styrene phosphonic acid, synthetic anionic polymeric polycarboxylate, maleic anhydride, maleic acid, and methyl vinyl ether.

20. The method of claim 18, wherein the particle has an average particle size of less than about 7 microns.

21. The method claim 18, wherein the particles have a porosity of less than about 0.45 cc/g in pores of about 600 Angstroms or smaller.

24. The method of claim 19, wherein the particle of the composition has an average particle size of less than about 7 microns.

22. A method of maintaining or increasing the systemic health of a mammal comprising applying a composition to an oral surface of a mammal at least once a day for a duration of time, wherein the composition comprises an adherent polymer, a silica particle having an average particle size of about 8 microns or less, wherein the particles are present in the composition in an amount of about 5% by weight or greater, and an agent selected from triclosan;

triclosan monophosphate;

chlorhexidine;

alexidine;

hexetidine;

sanguinarine;

benzalkonium chloride;

salicylanilide;

domiphen bromide;

cetylpyridinium chloride (CPC);

tetradecylpyridinium chloride (TPC);

N-tetradecyl-4-ethylpyridinium chloride (TDEPC);

octenidine;

delmopinol;

octapinol;

nisin;

zinc ion agent;

copper ion agent;

essential oils;

furanones;

bacteriocins, ethyl lauroyl arginate, extracts of magnolia, a metal ion source, arginine bicarbonate, honokiol, magonol, ursolic acid, ursic acid, morin, extract of sea buckthorn, a peroxide, an enzyme, a Camellia extract, a flavonoid, a flavan, halogenated diphenyl ether, creatine, and propolis.

23. The method of claim 22, wherein the duration of time is about 1 month to about 1 year.

25. A method of occluding a dentin tubule within the surface of a mammalian tooth comprising applying to the tooth surface a composition comprising an adherent material and a silica particle having an average particle size of about no greater than a dentin tubule.