METHOD OF PRODUCING TISSUE BY PLACING A MOLDING SUPPORT WITHIN A BODY CAVITY
First Claim
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1. A method of producing a tissue, comprising placing a molding support within a peritoneal cavity for a time and under conditions sufficient for non-vascularized tissue comprising myofibroblasts to form on the molding support and grafting the tissue into a recipient.
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Abstract
A method of producing a tissue includes placing a molding support within a body cavity for a time and under conditions sufficient for non-vascularized tissue comprising myofibroblasts to form on the molding support. In some embodiments, the tissue produced by this method is particularly useful as vascular tissue for the treatment or prophylaxis of diseased or damaged blood vessels such as in atherosclerosis.
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Citations
20 Claims
- 1. A method of producing a tissue, comprising placing a molding support within a peritoneal cavity for a time and under conditions sufficient for non-vascularized tissue comprising myofibroblasts to form on the molding support and grafting the tissue into a recipient.
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18. The method of producing a tissue, comprising placing a molding support within a peritoneal cavity for a time and under conditions sufficient for non-vascularized tissue comprising myofibroblasts to form on the molding support and grafting the tissue into a recipient, wherein the molding support is a tube and wherein the method further comprises placing the tube into the peritoneal cavity using a prosthetic device that comprises:
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an outer elongated tubular member having perforations or a permeable layer to permit passage of cells and fluid into and out of the tubular member; an inner elongated member removably insertable in the outer elongated member and comprising the tube around which or part of which vascular or non-vascular tissue can grow; and an external portion which is maintained on the skin surface or subcutaneously and through which the inner elongated member can be removed from the outer elongated member. - View Dependent Claims (19, 20)
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Specification