COLLAGEN CARRIER OF THERAPEUTIC GENETIC MATERIAL, AND METHOD

• US 20080268053A1
• Filed: 10/30/2007
• Published: 10/30/2008
• Est. Priority Date: 02/22/1995
• Status: Abandoned Application

• Current Assignee: ED. Geistlich Soehne AG Fuer Chemische Industrie
• Original Assignee: ED. Geistlich Soehne AG Fuer Chemische Industrie
• Inventors: Schloesser, Lothar, Geistlich, Peter
• Application Number:
  US11/928,387
• Publication Number:
  US 20080268053A1
• Time in Patent Office: Days
• US Class Current: 424/484
• CPC Class Codes: A61B 17/00234 for minimally invasive surgery A61B17/0218, A61B17/0469, A61B17/12013, A61B17/1285, A61B17/29, A61B17/320016 take precedence
• CPC Class Codes: A61B 17/00491 Surgical glue applicators surgical adhesives A61L24/00; two-component delivery syringes A61M5/19
• CPC Class Codes: A61B 17/06166 Sutures suture materials A61L17/00; manufacture of artificial threads D01D; treatment of threads D06M
• CPC Class Codes: A61F 2/0077 Special surfaces of prostheses, e.g. for improving ingrowth A61F2/30767 takes precedence
• CPC Class Codes: A61F 2/28 Bones joints A61F2/30
• CPC Class Codes: A61F 2/30756 Cartilage endoprostheses A61F2/3603 takes precedence
• CPC Class Codes: A61F 2/30767 Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
• CPC Class Codes: A61F 2002/0086 for preferentially controlling or promoting the growth of specific types of cells or tissues
• CPC Class Codes: A61F 2002/009 for hindering or preventing attachment of biological tissue
• CPC Class Codes: A61F 2002/2817 Bone stimulation by chemical reactions or by osteogenic or biological products for enhancing ossification, e.g. by bone morphogenetic or morphogenic proteins [BMP] or by transforming growth factors [TGF]
• CPC Class Codes: A61F 2002/30062 (bio)absorbable, biodegradable, bioerodable, (bio)resorbable, resorptive
• CPC Class Codes: A61F 2002/30677 Means for introducing or releasing pharmaceutical products, e.g. antibiotics, into the body
• CPC Class Codes: A61F 2002/30761 Support means for artificial cartilage, e.g. cartilage defect covering membranes
• CPC Class Codes: A61F 2002/3093 for promoting ingrowth of bone tissue
• CPC Class Codes: A61F 2002/30932 for retarding or preventing ingrowth of bone tissue
• CPC Class Codes: A61F 2002/30971 Laminates, i.e. layered products
• CPC Class Codes: A61F 2002/4635 using minimally invasive surgery
• CPC Class Codes: A61F 2210/0004 bioabsorbable
• CPC Class Codes: A61F 2240/001 Designing or manufacturing processes
• CPC Class Codes: A61F 2310/00365 Proteins; Polypeptides; Degradation products thereof
• CPC Class Codes: A61F 2310/00982 : Coating made of collagen
• CPC Class Codes: A61L 2300/258 : Genetic materials, DNA, RNA, genes, vectors, e.g. plasmids
• CPC Class Codes: A61L 2300/412 : Tissue-regenerating or healing or proliferative agents
• CPC Class Codes: A61L 2430/06 : for cartilage reconstruction, e.g. meniscus
• CPC Class Codes: A61L 27/20 : Polysaccharides
• CPC Class Codes: A61L 27/24 : Collagen
• CPC Class Codes: A61L 27/26 : Mixtures of macromolecular compounds
• CPC Class Codes: A61L 27/3654 : Cartilage, e.g. meniscus
• CPC Class Codes: A61L 27/3817 : Cartilage-forming cells, e.g. pre-chondrocytes
• CPC Class Codes: A61L 27/3847 : Bones
• CPC Class Codes: A61L 27/3852 : Cartilage, e.g. meniscus
• CPC Class Codes: A61L 27/54 : Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: A61L 31/005 : Ingredients of undetermined constitution or reaction products thereof
• CPC Class Codes: A61L 31/041 : Mixtures of macromolecular compounds
• CPC Class Codes: A61L 31/044 : Collagen
• CPC Class Codes: A61L 31/16 : Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: A61P 19/00 : Drugs for skeletal disorders
• CPC Class Codes: C08L 5/08 : Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
• CPC Class Codes: C08L 89/06 : derived from leather or skin , e.g. gelatin

Abstract

A collagen matrix material is charged with a cell growth-promoting derived nucleic acid sequence. The nucleic acid sequence-charged collagen matrix material may be utilized in a method of promoting regeneration of surface cartilage of a joint. In the method, an area of injury is covered with the nucleic acid sequence-charged collagen matrix material, the collagen matrix material is fixed over the area to be treated, and the area is allowed to heal.

Claims

1. A collagen matrix material comprising a matrix formed substantially of collagen II, said matrix carrying a nucleic acid sequence encoding a protein that promotes cell growth, wherein said matrix has an open sponge-like texture.

2. The collagen matrix material of claim 1 wherein said sequence is an isolated nucleic acid sequence.

3. The collagen matrix material of claim 1 wherein said sequence is an isolated gene sequence.

4. The collagen matrix material of claim 1 wherein said sequence is an isolated DNA sequence.

5. The collagen matrix material of claim 1 wherein said sequence promotes cartilage growth.

6. The collagen matrix material of claim 1 wherein said sequence promotes bone growth.

7. A method of promoting regeneration of surface cartilage of a joint, comprising covering an area of damaged cartilage of a joint to be treated, with a collagen matrix material according to claim 1, said collagen matrix material carrying a cell growth-promoting nucleic acid sequence;

fixing said collagen matrix material over said area; and

allowing said area to regenerate cartilage.

8. A method of repairing injury or damage to bone, cartilage or a combination thereof, comprising covering an area to be treated of injured or damaged bone, cartilage or a combination thereof, with a collagen matrix material according to claim 1, said collagen matrix material carrying a cell growth-promoting derived nucleic acid sequence;

fixing said collagen matrix material over said area; and

allowing said area to heal.

9. The method of claim 8 wherein said area is a dental area, maxilofacial area or spinal area.

10. The material of claim 1 wherein said collagen II is derived from cartilage.

11. The material of claim 1 wherein the collagen II is substantially telopeptide-free.

12. The material of claim 1 wherein the matrix material has a thickness of about 0.2-12 mm.

13. The material of claim 1 wherein the matrix material has a thickness of about 1-6 mm.

14. The method of claim 7 wherein prior to said covering, a cartilage defect is removed from said area.

15. The method of claim 7 wherein prior to said covering, a plurality of punctures are made to a subchondral plate of said area.