DUAL MEASUREMENT ANALYTE DETECTION SYSTEM

• US 20080268486A1
• Filed: 07/10/2008
• Published: 10/30/2008
• Est. Priority Date: 04/15/2003
• Status: Abandoned Application

• Current Assignee: OptiScan Biomedical Corporation
• Original Assignee: OptiScan Biomedical Corporation
• Inventors: Braig, James R., Sterling, Bernhard B., Hartstein, Philip C., Rule, Peter, Witte, Kenneth G.
• Application Number:
  US12/171,205
• Publication Number:
  US 20080268486A1
• Time in Patent Office: Days
• US Class Current: 435/14
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters

Abstract

An analyte detection system is configured to measure concentrations of at least first and second analytes in a single material sample supported by a sample element. The measurement of a second analyte can be conditioned on a quantitative or qualitative result of the first measurement. In one embodiment, the first analyte is glucose and the second analyte is a ketone. According to such an embodiment the ketone is measured if the result of the glucose measurement exceeds a previously-specified value or falls outside of a previously-specified range.

Claims

1. An analyte detection system for detecting more than one analyte, the system comprising:

an analyte detector in fluid communication with a source of a material sample and configured to measure a first characteristic of the material sample;

a processing circuit in electronic communication with the analyte detector, the processing circuit configured to use the first measured characteristic to determine the concentration of a first analyte in the material sample and compare the concentration of said first analyte to a range given by an upper and a lower value of concentration, the processing circuit further configured to activate said analyte detection device to measure a second characteristic of said material sample, if the concentration of the first analyte is outside the range, and use the second measured characteristic to determine the concentration of a second analyte.

2. The system of claim 1, wherein said upper value of said range is at least about 200 mg/dL of said first analyte.

3. The system of claim 1, further comprising an alert device coupled to the processing circuit, wherein the processing circuit is further configured to activate the alert device when said concentration of said first analyte is outside of said range.

4. The system of claim 1, wherein said first analyte is glucose.

5. The system of claim 1, wherein the second analyte is a ketone.

6. The system of claim 5, wherein the second analyte is selected from the group consisting of beta-hydroxy-butyrate, acetoacetate and acetone.

52. The system of claim 1, wherein the analyte detector is further configured to measure the first characteristic of the material sample by radiating the sample with radiation within a first range of wavelengths from which the first analyte can be detected in the material sample.

7. An analyte detection system for detecting more than one analyte, the system comprising:

a disposable sample element in fluid communication with a source of a material sample; and

an analyte detection device operatively coupled to said sample element,

said sample element configured to receive a portion of the material sample for analysis, the portion of the material sample comprising a first analyte,

said analyte detection device configured to measure a characteristic of the first analyte, said characteristic being associated with the concentration of said first analyte in said material sample.

8. The system of claim 7, further comprising a processing circuit in communication with said analyte detection device, said processing circuit enabled to determine the concentration of the first analyte in said material sample from the characteristic measured by the analyte detection device and subsequently communicating with the analyte detection device to measure a characteristic of a second analyte in said material sample and determine the concentration of the second analyte in the material sample.

10. The system of claim 8, wherein the processing circuit is further configured to activate the analyte detection to measure a characteristic of a second analyte in the material sample if the concentration of the first analyte less than a first value or greater than a second value.

11. The system of claim 10, wherein said second value is at least 180 mg/dl.

12. The system of claim 7, wherein said analyte detection device is an optical spectroscopy device.

13. The system of claim 12, wherein said analyte detection device comprises an array of optical filters.

14. The system of claim 13, wherein said array of optical filters comprises a filter wheel.

15. The system of claim 13, wherein said array of optical filters comprises an electronically tunable filter.

55. The system of claim 7, wherein the analyte detection device further comprises an optical source and a photo-detector defining an optical path therebetween.

9. (canceled)

16. (canceled)

17. (canceled)

18. (canceled)

19. (canceled)

20. (canceled)

21. A method for determining concentrations of a plurality of analytes in a sample, the method comprising:

providing a source of fluid;

providing an analyte detection system;

operatively associating the analyte detection system with the source of fluid;

withdrawing a portion of the fluid from the source with said analyte detection system, said fluid portion comprising a first analyte and a second analyte;

measuring a characteristic of the fluid portion with said analyte detection system, said characteristic being associated with the concentration of the first analyte;

determining the concentration of the first analyte from the measured characteristic of the fluid portion;

comparing the determined value of the concentration of the first analyte to an upper concentration value and a lower concentration value to determine if the concentration of the first analyte is within a range of values between the upper and lower concentration values; and

measuring a characteristic of the second analyte with the analyte detection system, said characteristic being associated with the concentration of the second analyte, if the concentration value of the first analyte is outside the range.

22. The method of claim 21, wherein said upper concentration value is at least about 200 mg/dl.

23. The method of claim 21, wherein said first analyte is glucose.

24. The method of claim 23, wherein the second analyte is a ketone.

25. The method of claim 24, wherein the second analyte is selected from the group consisting of beta-Hydroxy-butyrate, acetoacetate and acetone.

26. The method of claim 21, further comprising simultaneously displaying a value corresponding to the concentration of said first analyte and a value corresponding to the concentration of the second analyte.

27. The method of claim 21, wherein the concentration is determined by the analyte detection system comprising a processing circuit.

28. A method of determining a medical condition using an analyte detection system, the method comprising:

attaching a fluidic system comprising a sample element to a source of bodily fluid;

engaging the fluidic system to withdraw a sample of the bodily fluid from said source;

communicating the withdrawn sample of bodily fluid to the sample element;

engaging an analyte detection system with the sample element, said analyte detection system comprising an optical source and a detector defining an optical path therebetween;

measuring a characteristic of a first analyte in said sample of bodily fluid, said characteristic being associated with the concentration of said first analyte;

determining the concentration of said first analyte in said sample of the bodily fluid;

configuring the analyte detection system to measure a characteristic of a second analyte in said sample of the bodily fluid without removing the sample of bodily fluid from the sample element; and

determining the concentration of the second analyte in said sample.

29. The method of claim 28, wherein the analyte detection system is configured to measure the characteristic of the second analyte after determining that the concentration of said first analyte exceeds a first value.

30. The method of claim 28, wherein the characteristic of the first analyte and the characteristic of the second analyte is measured using optical spectroscopy.

31. The method of claim 30, wherein said optical spectroscopy includes providing a filter array for analyzing an intensity of electromagnetic radiation having a wavelength of about 10.55 μ

m and about 10.7 μ

m.

32. The method of claim 31, wherein said measurement of said second characteristic comprises allowing a total dwell time for said filter array of between about 30 and about 40 seconds.

33. The method of claim 28, wherein said measuring said second characteristic of said second analyte is performed using absorption spectroscopy.

34. The method of claim 33, wherein said absorption spectroscopy includes providing a filter array for analyzing an intensity of electromagnetic radiation having wavelengths associated with the first and second analytes.

35. The method of claim 34, wherein said measurement of said second characteristic comprises allowing a dwell time for the filter array of between about 15 and about 20 seconds.

36. The method of claim 28, further comprising simultaneously displaying concentration values of both said first and said second analyte concentrations.

37-51. -51. (canceled)