Methods and compositions for treating hypoglycemic disorders
First Claim
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1. A method of treating a subject with a congenital hyperinsulinism, or neonatal hyperinsulinism, comprising the step of administering to said subject an antagonist of the Glucagon Like Peptide-1 (GLP-1) receptor, thereby decreasing basal intracellular cAMP and treating a subject with a congenital hyperinsulinism.
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Abstract
This invention relates to methods of treating and ameliorating congenital and neonatal hyperinsulinism and post-prandial hypoglycemia, comprising the step of administering an antagonist of the Glucagon-Like Peptide-1 (GLP-1) receptor, e.g. a GLP-1 fragment or analogue thereof.
22 Citations
19 Claims
- 1. A method of treating a subject with a congenital hyperinsulinism, or neonatal hyperinsulinism, comprising the step of administering to said subject an antagonist of the Glucagon Like Peptide-1 (GLP-1) receptor, thereby decreasing basal intracellular cAMP and treating a subject with a congenital hyperinsulinism.
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2. A method of inhibiting or suppressing congenital hyperinsulinism or neonatal hyperinsulinism, comprising the step of administering to said subject an antagonist of the Glucagon Like Peptide-1 (GLP-1) receptor, thereby decreasing basal intracellular cAMP and inhibiting or suppressing congenital hyperinsulinism.
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3. A method of reducing symptoms associated with congenital hyperinsulinism or neonatal hyperinsulinism, comprising the step of administering to said subject an antagonist of the Glucagon Like Peptide-1 (GLP-1) receptor, thereby decreasing basal intracellular cAMP and reducing symptoms associated with congenital hyperinsulinism
- 14. A method of reducing an incidence of hypoglycemia in a subject with neonatal HI, comprising the step of administering to said subject an antagonist of the Glucagon Like Peptide-1 (GLP-1) receptor, thereby decreasing basal intracellular cAMP and reducing an incidence of hypoglycemia in a subject with neonatal HI.
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