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Chimeric Vectors

  • US 20080269149A1
  • Filed: 12/15/2005
  • Published: 10/30/2008
  • Est. Priority Date: 12/15/2004
  • Status: Active Grant
First Claim
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1. A chimeric virus vector comprising:

  • (a) a chimeric adeno-associated virus (AAV) capsid comprising a selective amino acid insertion following amino acid position 264 in an AAV2 capsid subunit or a corresponding change in a capsid subunit from other AAV; and

    (b) a nucleic acid comprising an AAV terminal repeat sequence and a heterologous nucleic acid sequence;

    wherein the nucleic acid is packaged within the chimeric AAV capsid.

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