INSTRUMENT FOR MEASURING CARBON MONOXIDE POISONING OF HUMANS USING IN VIVO NIRS TECHNOLOGY
First Claim
1. A method for non-invasively determining the relative amounts of a plurality of chromophores in the blood of a human or animal subject, the method comprising the steps of:
- imparting a wavelength range of light comprising visible and near-infrared components to a light delivery fiberoptic;
passing the wavelength range of light through a selected tissue sample of the human or animal subject and receiving an unabsorbed portion of the wavelength range of light in a light collecting fiberoptic;
providing a spectrometer for receiving the unabsorbed portion of the wavelength range of light from the light collecting fiberoptic;
determining a total absorption spectrum of the selected tissue sample for a plurality of wavelengths selected from the wavelength range of light; and
comparing an absorption of the plurality of chromophores at a first wavelength to an absorption of the plurality of chromophores at one or more additional wavelengths to determine a relative amount of each of the plurality of chromophores in the blood of a human or animal subject.
1 Assignment
0 Petitions
Accused Products
Abstract
Spectral, frequency based non-invasive procedure for determination of blood constituents utilizing in vivo NIRS (Near-Infrared Spectrum) technology, which is the measurement of the near-infrared absorption spectrum within a region of the living human body for the purpose of identifying tissue and blood components and their concentrations and more particularly to novel applications and methodology for determining the optical response, measurements and calculations relating to the concentrations of individual chromophores in the bloodstream and particularly to the level of CO chromophores in the tissues of an animal or human being.
-
Citations
20 Claims
-
1. A method for non-invasively determining the relative amounts of a plurality of chromophores in the blood of a human or animal subject, the method comprising the steps of:
-
imparting a wavelength range of light comprising visible and near-infrared components to a light delivery fiberoptic; passing the wavelength range of light through a selected tissue sample of the human or animal subject and receiving an unabsorbed portion of the wavelength range of light in a light collecting fiberoptic; providing a spectrometer for receiving the unabsorbed portion of the wavelength range of light from the light collecting fiberoptic; determining a total absorption spectrum of the selected tissue sample for a plurality of wavelengths selected from the wavelength range of light; and comparing an absorption of the plurality of chromophores at a first wavelength to an absorption of the plurality of chromophores at one or more additional wavelengths to determine a relative amount of each of the plurality of chromophores in the blood of a human or animal subject. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
-
-
9. An apparatus for non-invasively determining the relative amounts of a plurality of chromophores in the blood of a human or animal subject comprising:
-
a light source imparting a wavelength range including visible and broadband infrared light to a light delivery fiberoptic; a light collecting fiberoptic for receiving the light after the light has passed through a selected tissue sample of the human or animal subject; and a spectrometer for measuring the intensity of substantially all wavelengths of light received by the light collecting fiberoptic. - View Dependent Claims (10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
-
Specification