ELECTROPORATION TO INTERRUPT BLOOD FLOW
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Accused Products
Abstract
A method for disrupting blood flow to undesirable tissue such as cells of a cancerous or non-cancerous tumor is disclosed. It involves the placement of electrodes into or near the vicinity of vessels supplying blood to the undesirable tissue and through the application of electrical pulses causing blood flow disruption. The electric pulses irreversibly permeate the cell membranes, thereby invoking cell death. The irreversibly permeabilized cells are left in situ and are removed by the body immune system. The process may further comprise monitoring blood flow and/or infusion of a material such as a chemotherapeutic agent or marker into the blood.
161 Citations
70 Claims
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1-36. -36. (canceled)
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37. A device for disrupting blood flow, comprising:
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first and second electrodes that position a blood vessel to be disrupted therebetween; a voltage generator means that applies a voltage between the first and second electrodes in a manner which provides a predetermined electric field around the blood vessel for a time sufficient to disrupt blood flow through the vessel. - View Dependent Claims (38, 39, 40, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70)
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41-53. -53. (canceled)
Specification