TEMPORAL CONTROL IN PHOTOTHERAPY
First Claim
1. An apparatus for delivering phototherapy comprising;
- at least one substrate configured to enable mounting at least one light emitter;
at least one emitter mounted on the at least one substrate, and capable of emitting at least two peak wavelengths of light; and
an electronic circuit configured to control the timing of emission of the at least one emitter,wherein the electronic circuit is in electronic communication with the at least one emitter, andwherein the apparatus is configured as a dressing for optical communication enabling irradiation of a target tissue.
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Accused Products
Abstract
An apparatus for delivering phototherapy includes at least one substrate, at least one emitter mounted on the substrate, and which emits at least two peak wavelengths of light, and an electronic circuit that controls emitter timing. The apparatus is configured as a dressing. A corresponding method includes delivering a first pulse of light to the target tissue from the emitter with a peak wavelength of light, and delivering at least a second pulse of light having a peak wavelength of light that is different from the peak wavelength of the first pulse of light, and the steps define a method of delivering a series of pulse sets of light, and the first and second pulses of light define a pulse set of light. Also disclosed are modular phototherapy units, control of timing of phototherapy by a perfusion detector, and use of long wavelength light for hyperbilirubinemia.
125 Citations
23 Claims
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1. An apparatus for delivering phototherapy comprising;
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at least one substrate configured to enable mounting at least one light emitter; at least one emitter mounted on the at least one substrate, and capable of emitting at least two peak wavelengths of light; and an electronic circuit configured to control the timing of emission of the at least one emitter, wherein the electronic circuit is in electronic communication with the at least one emitter, and wherein the apparatus is configured as a dressing for optical communication enabling irradiation of a target tissue. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. An apparatus for phototherapy to target tissue of a subject, comprising
at least one light source configured to deliver phototherapy with a peak wavelength between 580 and 1350 nm; -
at least one light sensor configured to detect light passing through the target tissue and changes in the light passing through the target tissue; and at least one processor configured to at least one of; (a) measure changes in at least one of blood volume and light absorption of the blood passing through the target tissue; (b) enable correlation with respect to the subject of the changes in the light passing through the target tissue with at least one of the timing of the pulse, the pulse pressure, the oxygen saturation of the blood, the hemoglobin content of the blood, and the respiratory cycle; and (c) control timing of delivery of phototherapy according a portion of the pulse cycle.
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13. A method of applying phototherapy to a subject, comprising the steps of:
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providing at least one light emitter; delivering a first pulse of light to the target tissue of a subject from the at least one emitter with a peak wavelength of light; and delivering at least a second pulse of light to the target tissue of the subject from the at least one emitter wherein the at least one emitter provides at least one peak wavelength of light that is different from the peak wavelength of the first pulse of light, wherein the steps of delivering a first pulse of light and of delivering a second pulse of light define a method of delivering a series of pulse sets of light, and wherein the first pulse of light and the second pulse of light define a pulse set of light. - View Dependent Claims (14, 15, 16, 17)
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18. A method for phototherapy for a subject comprising the steps of:
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providing at least one light source emitting light with a peak wavelength less than about 500 nanometers; providing at least a second light source emitting light with at least one peak wavelength ranging between about 565 nanometers and about 700 nanometers (nm); delivering the light with a peak wavelength of less than about 500 nanometers to tissue of the subject for a time period of greater than about one hour; and at least partially concurrently delivering the light with a peak wavelength ranging between about 565 and about 700 nanometers for a time period of greater than about one hour. - View Dependent Claims (19)
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20. A method of timing delivery of phototherapy to a subject comprising the steps of:
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measuring at least one phase of the circulatory cycle of the subject; identifying a desired phase of the at least one phase of the circulatory cycle of the subject wherein the desired phase is beneficial for delivery of phototherapy to the subject; and delivering phototherapy to the subject during at least a portion of the desired phase of the circulatory cycle of the subject. - View Dependent Claims (21)
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22. A method of phototherapy treatment comprising the steps of:
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providing at least one light emitter, and irradiating target tissue of a subject with light from the at least one emitter for sufficient time to give therapeutic effect, wherein the at least one emitter is at least one of; (a) a blue emitter emitting light with a peak wavelength less than 500 nanometers (nm), the light emitted from the blue emitter being at least a portion of the light irradiating the tissue from the at least one emitter, the blue emitter coupled with one of a phosphor and a scintillator, the phosphor and the scintillator emitting light at least one peak wavelength longer than 500 nanometers (nm), the light from the one of a phosphor and a scintillator being at least a portion of the light irradiating the tissue from the at least one emitter; (b) a light emitting diode emitting white light, the white light emitted from the light emitting diode being at least a portion of the light irradiating the tissue from the at least one emitter; (c) configured to emit light cycling in intensity at a rate of at least one cycle per second, the light from the at least one emitter cycling in intensity being at least a portion of the light irradiating the tissue from the at least one emitter; and (d) configured to emit light delivering a pulse of irradiation with a duration of less than one second, the light from the at least one emitter delivering a pulse of irradiation with a duration of less than one second being at least a portion of the light irradiating the tissue from the at least one emitter. - View Dependent Claims (23)
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Specification