System and Method for Precise Liquid Measurement in a Liquid Sampling Pipette
First Claim
1. A method of regulating a requested volume of liquid in a liquid handling pipette by correcting for a current physical condition at the pipette, the method comprising:
- selecting a requested volume at a pipette, the pipette including a piston drive mechanism, the piston drive mechanism configured to contact a piston assembly to move a piston rod of the piston assembly within a tip holder thereby causing regulation of an amount of liquid in the tip holder, the requested volume representing the amount of liquid to regulate;
calculating a correction volume using a volume characterization, wherein the volume characterization characterizes a difference in the amount of the liquid regulated in the tip holder as a function of the requested volume, the volume characterization determined using a calibration process; and
displaying the correction volume to a user of the pipette thereby regulating the requested volume of liquid in the tip holder.
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Accused Products
Abstract
A device and method are provided for correcting a requested volume of liquid to aspirate/dispense by a liquid-handling pipette based on the requested volume and/or a physical condition at the pipene. The pipette includes a piston drive mechanism configured to contact a piston assembly and move a piston rod of the piston assembly within a tip holder thereby causing regulation of an amount of liquid in the tip holder. The method includes selecting a requested volume at a pipette, the requested volume representing the amount of liquid to regulate, calculating a correction volume using a volume characterization, wherein the volume characterization characterizes a difference in the amount of the liquid regulated in the tip holder as a function of the requested volume, and displaying the correction volume to a user of the pipette thereby regulating the requested volume of liquid in the tip holder. The volume characterization is determined using a calibration process.
51 Citations
26 Claims
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1. A method of regulating a requested volume of liquid in a liquid handling pipette by correcting for a current physical condition at the pipette, the method comprising:
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selecting a requested volume at a pipette, the pipette including a piston drive mechanism, the piston drive mechanism configured to contact a piston assembly to move a piston rod of the piston assembly within a tip holder thereby causing regulation of an amount of liquid in the tip holder, the requested volume representing the amount of liquid to regulate; calculating a correction volume using a volume characterization, wherein the volume characterization characterizes a difference in the amount of the liquid regulated in the tip holder as a function of the requested volume, the volume characterization determined using a calibration process; and displaying the correction volume to a user of the pipette thereby regulating the requested volume of liquid in the tip holder. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. A device for regulating a requested volume of liquid in a liquid handling pipette by correcting for a current physical condition of the pipette, the device comprising:
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a body case; a tip holder, the tip holder mounted to the body case; a piston assembly, the piston assembly mounted to the tip holder and comprising a piston rod that fits within the tip holder; a piston drive mechanism, the piston drive mechanism comprising a control rod having a surface that contacts the piston assembly, the piston drive mechanism configured to move the piston rod of the piston assembly within the tip holder thereby causing regulation of a liquid in the tip holder; a volume selector, the volume selector mounted to the body case and configured to allow a user to select a requested volume, the requested volume representing the amount of liquid to regulate; a display, the display mounted to the body case; a processor, the processor coupled to the display and to the volume selector and configured to calculate a correction volume using a volume characterization, wherein the volume characterization characterizes a difference in the amount of the liquid regulated in the tip holder as a function of the requested volume, the volume characterization determined using a calibration process; wherein the display indicates the correction volume to a user of the pipette thereby regulating the requested volume of liquid in the tip holder. - View Dependent Claims (15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26)
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Specification