SKIN PERMEATION DEVICE FOR ANALYTE SENSING OR TRANSDERMAL DRUG DELIVERY
First Claim
1. A controlled abrasion device comprising a hand piece, an abrasive tip, a feedback control mechanism, a source electrode, a return electrode, and an electrical motor, wherein the source electrode is located in the abrasive tip.
1 Assignment
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Accused Products
Abstract
Devices, systems, kits and methods for increasing the skin'"'"'s permeability controlled by measured skin electrical parameter are described herein. They may be used for transdermal drug delivery and/or analyte extraction or measurement. The controlled abrasion device contains (i) a hand piece, (ii) an abrasive tip, (iii) a feedback control mechanism, (iv) two or more electrodes, and (v) an electrical motor. The feedback control mechanism may be an internal feedback control mechanism or an external feedback control. The kit contains the controlled abrasion-device, one or more abrasive tips, optionally with a wetting fluid. The method for increasing the skin'"'"'s permeability requires applying the controlled abrasion device to a portion of the skin'"'"'s surface for a short period of time, until the desired level of permeability is reached. Then the abrasion device is removed, and a drug delivery composition or device or an analyte sensor is applied to the treated site.
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Citations
30 Claims
- 1. A controlled abrasion device comprising a hand piece, an abrasive tip, a feedback control mechanism, a source electrode, a return electrode, and an electrical motor, wherein the source electrode is located in the abrasive tip.
- 10. A controlled abrasion device comprising a hand piece, an abrasive tip, an external feedback control mechanism, a source electrode, a return electrode, a locating ring, and an electrical motor, wherein the source electrode is located in the locating ring.
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13. A method for reducing the impedance of a tissue site comprising
applying a controlled abrasion device to the tissue site, wherein the device comprises a hand piece, an abrasive tip, a feedback control mechanism, a source electrode, a return electrode, and an electrical motor placing the abrasive tip on the tissue site, turning the electrical motor on, and measuring an electrical parameter of the tissue site.
- 25. A kit for reducing the impedance of a tissue site comprising a controlled abrasion device, one or more abrasive tips, and a wetting fluid, wherein the abrasion device comprises a hand piece, a feedback control mechanism, and an electrical motor, and wherein the abrasive tip comprises an abrasive material and a source electrode.
Specification