IMPLANTABLE HIGH EFFICIENCY DIGITAL STIMULATION DEVICE

• US 20080275531A1
• Filed: 05/02/2008
• Published: 11/06/2008
• Est. Priority Date: 05/04/2007
• Status: Abandoned Application

• Current Assignee: Kenergy, Inc.
• Original Assignee: Kenergy, Inc.
• Inventors: Denker, Stephen, Bulkes, Cherik
• Application Number:
  US12/114,564
• Publication Number:
  US 20080275531A1
• Time in Patent Office: Days
• US Class Current: 607/62
• CPC Class Codes: A61B 5/301 providing electrical separation, e.g. by using isolating transformers or optocouplers
• CPC Class Codes: A61B 5/308 for electrocardiography [ECG]
• CPC Class Codes: A61N 1/36114 Cardiac control, e.g. by vagal stimulation stimulating the heart A61N1/362
• CPC Class Codes: A61N 1/3614 based on impedance measurement
• CPC Class Codes: A61N 1/36167 Timing, e.g. stimulation onset
• CPC Class Codes: A61N 1/36185 Selection of the electrode configuration
• CPC Class Codes: A61N 1/3622 comprising two or more electrodes co-operating with different heart regions
• CPC Class Codes: A61N 1/36514 controlled by a physiological quantity other than heart potential, e.g. blood pressure controlled by two or more physical parameters A61N1/36585
• CPC Class Codes: A61N 1/378 Electrical supply

Abstract

An implantable device provides artificial electrical stimulation of animal tissue using a plurality of electrodes. A sensing unit detects a physiological parameter at a stimulation site. A control unit governs the stimulation, in response to the detected physiological parameter, by selecting certain pairs of the electrodes and by defining the shape, duration, and duty cycle of a segmented stimulation waveform. A stimulation signal generator produces the segmented stimulation waveform that has a first segment and a second segment that with respect to the first segment is longer in duration lesser in magnitude and opposite in polarity.

Claims

1. An implantable apparatus for artificial electrical stimulation of tissue in a patient, the apparatus comprising:

a plurality of electrodes in contact with the tissue at one or more locations inside the patient; and

an implantable stimulator comprising;

(a) a power supply furnishing energy for the artificial electrical stimulation,

(b) a control unit for controlling the artificial electrical stimulation by programmable selection of at least some of the plurality of electrodes, and

(c) a stimulation signal generator connected to the control unit and producing a segmented stimulation waveform comprising a positive a segment, a pause segment, and a negative segment, wherein the segmented stimulation waveform is controlled by the control unit with respect to shape, duration and duty cycle.

2. The apparatus as recited in claim 1 further comprising a voltage intensifier connected to stimulation signal generator for increasing voltage of the segmented stimulation waveform to produce an output waveform that is applied to at least one of the plurality of electrodes.

3. The apparatus as recited in claim 2 wherein the voltage intensifier is one of a flying capacitor-type voltage doubler, bipolar mode voltage doubler, or a combination of a flying capacitor type and a bipolar mode voltage doubler.

4. The apparatus as recited in claim 1 wherein the segmented stimulation waveform is altered in response to a feedback signal received from a location inside the patient.

5. The apparatus as recited in claim 1 wherein the control unit adjusts duration of the segmented stimulation waveform by:

(a) decreasing the duration of the segmented stimulation waveform applied to a pair electrodes until the tissue fails to respond to such stimulation which determines a first duration value,

(b) thereafter increasing the duration of the segmented stimulation waveform applied to the pair electrodes until the tissue respond to such stimulation which determines a second duration value, and

(c) defining a duration setpoint that is between the first duration value and the second duration value, inclusive, wherein the duration setpoint is used in producing a subsequent segmented stimulation waveform.

6. The apparatus as recited in claim 1 wherein the segmented stimulation waveform has a first segment with a first amplitude, and a second segment that is longer in duration than the first segment and that has a second amplitude which is opposite in polarity and lesser in absolute magnitude to the first amplitude.

7. The apparatus as recited in claim 1 wherein the power supply is radio frequency based, piezoelectric device based, thermal energy source based, mechanical energy source based, or chemical energy source based.

8. The apparatus as recited in claim 1 wherein stimulation electrodes are located near a desired stimulation site.

9. The apparatus as recited in claim 8 wherein the stimulation site is selected from an intravascular location, a transvascular location, a muscle location, a transcutaneous location, and a nerve location.

10. The apparatus as recited in claim 1 wherein the control unit comprises a conventional microcomputer with analog and digital input/output circuits and an internal memory storing a software control program.

11. The apparatus as recited in claim 1 further comprising a sensing unit for detecting at least one physiological parameter from a site of stimulation.

12. The apparatus as recited in claim 11 wherein the sensing unit comprises an instrumentation amplifier with ungrounded, electrically floating inputs that receive signals from electrodes adapted to contact the tissue.

13. The apparatus as recited in claim 1 further comprising a sensing unit for detecting at least one physiological parameter, and comprising an electrode pair for implantation inside the patient, an instrumentation amplifier having an internal voltage reference, a passive filter coupling the electrode pair to the instrumentation amplifier.

14. An implantable apparatus for artificial electrical stimulation of tissue in a patient, the apparatus comprising:

a plurality of electrodes in contact with the tissue at one or more locations inside the patient;

a power supply furnishing energy for the artificial electrical stimulation,

an implantable control unit for controlling the artificial electrical stimulation by programmable selection of at least some of the plurality of electrodes, and by selection of a stimulation waveform;

a stimulation signal generator connected to the control unit and producing a segmented stimulation waveform that has a first segment with a first amplitude of a first polarity, and a second segment that is longer in duration than the first segment, wherein the second segment has a second amplitude which lesser in absolute magnitude that the first amplitude, and has a second polarity opposite to the first polarity.

15. The apparatus as recited in claim 14 further comprising a voltage intensifier connected to stimulation signal generator for increasing voltage of the segmented stimulation waveform to produce an output waveform that is applied to at least one of the plurality of electrodes.

16. The apparatus as recited in claim 15 wherein the voltage intensifier is one of a flying capacitor-type voltage doubler, bipolar mode voltage doubler, or a combination of a flying capacitor type and a bipolar mode voltage doubler.

17. The apparatus as recited in claim 14 wherein the stimulation waveform is altered in response to a feedback signal received from a location inside the patient.

18. The apparatus as recited in claim 14 wherein the segmented stimulation waveform is variable in shape, duration, and duty cycle for maximizing energy conservation and avoiding stimulation sensation to the patient.

19. The apparatus as recited in claim 14 wherein the power supply is radio frequency based, piezoelectric device based, thermal energy source based, mechanical energy source based or chemical energy source based.

20. The apparatus in claim 14 wherein the one or more locations inside the patient is one of an intravascular location, a transvascular location, a muscle location, a transcutaneous location and a nerve location.

21. An implantable apparatus for artificial electrical stimulation of tissue in a patient, the implantable apparatus comprising:

a plurality of electrodes in contact with the tissue at one or more locations inside the patient;

a power supply furnishing energy to the apparatus;

an implantable control unit comprising a microcomputer with analog and digital input/output circuits and an internal memory storing a software control program;

a stimulation signal generator controlled by the control unit and producing a segmented voltage waveforms across pairs of the plurality of electrodes to stimulate the tissue, wherein the segmented voltage waveforms are variable in shape, duration, and duty cycle.

22. The implantable apparatus as recited in claim 21 further comprising a sensing unit that comprises an electrode pair for implantation inside the patient to sense biological signals, an instrumentation amplifier having an internal voltage reference, a passive filter coupling the electrode pair to the instrumentation amplifier.

23. The implantable apparatus as recited in claim 21 further comprising a sensing unit for detecting at least one physiological parameter from a site of stimulation, wherein the sensing unit comprises an amplifier with ungrounded, electrically floating inputs that receive signals from electrodes at the site of stimulation.

24. The apparatus as recited in claim 21 wherein at least one of the segmented voltage waveforms has a first segment with a first amplitude of a first polarity, and a second segment that is longer in duration than the first segment, wherein the second segment has a second amplitude which lesser in absolute magnitude that the first amplitude, and has a second polarity opposite to the first polarity.