TREATMENT PROTOCOL GENERATION FOR DISEASES RELATED TO ANGIOGENESIS

• US 20080275684A1
• Filed: 06/03/2008
• Published: 11/06/2008
• Est. Priority Date: 10/25/2001
• Status: Abandoned Application

• Current Assignee: Optimatal Limited
• Original Assignee: Optimatal Limited
• Inventors: Vainstein, Vladimir, Arakelyan, Levon, Agur, Zvia
• Application Number:
  US12/132,300
• Publication Number:
  US 20080275684A1
• Time in Patent Office: Days
• US Class Current: 703/11
• CPC Class Codes: G01F 1/3218 bluff body design
• CPC Class Codes: G01F 1/3266 by sensing mechanical vibrations
• CPC Class Codes: G01F 1/3273 for detecting fluid speed oscillations by thermal sensors
• CPC Class Codes: G01F 1/86 Indirect mass flowmeters, e.g. measuring volume flow and density, temperature or pressure
• CPC Class Codes: G01N 2333/515 Angiogenesic factors; Angiogenin
• CPC Class Codes: G01N 33/74 involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors

Abstract

A computer-implemented method for determining an optimal treatment protocol for a disease related to angiogenesis, comprising creating an angiogenesis model including pro-angiogenesis and anti-angiogenesis factors. Effective vessel density (EVD) is incorporated as a factor regulating switching on and switching off of at least one component in the angiogenesis model. Effects of vasculature maturation and mature vessels destabilization are incorporated. Pro-angiogenesis and anti-angiogenesis factors, which can influence changes in state of a tissue are selected. Effects of drugs in the pro-angiogenesis and anti-angiogenesis factors are incorporated. A plurality of treatment protocols in a protocol space is generated. A best treatment protocol based on a pre-determined criteria.

Claims

1. A computer-implemented method for determining an optimal treatment protocol for a disease related to angiogenesis, comprising:

creating an angiogenesis model including pro-angiogenesis and anti-angiogenesis factors;

incorporating effects of vasculature maturation and mature vessels destabilization;

selecting pro-angiogenesis and anti-angiogenesis factors, which can influence changes in state of a tissue;

incorporating effects of drugs in the pro-angiogenesis and anti-angiogenesis factors;

generating a plurality of treatment protocols in a protocol space; and

selecting a best treatment protocol based on a pre-determined criteria.

2. A system for determining an optimal treatment protocol for a disease related to angiogenesis, comprising:

an angiogenesis model including pro-angiogenesis and anti-angiogenesis factors;

a treatment protocol space generator that generates a protocol space of possible treatments for the disease;

a treatment selector that selects an optimal protocol,

wherein the model incorporates effects of vasculature maturation and mature vessels destabilization;

wherein the system is adapted to effect selection of pro-angiogenesis and anti-angiogenesis factors which can influence changes in state of a tissue and incorporating effects of drugs in the pro-angiogenesis and anti-angiogenesis factors.

3. A computer program product, including computer-readable media comprising instructions to implement procedures for determining an optimal treatment protocol for a disease related to angiogenesis, said procedure comprising:

creating an angiogenesis model including pro-angiogenesis and anti-angiogenesis factors;

incorporating effects of vasculature maturation and mature vessels destabilization;

selecting pro-angiogenesis and anti-angiogenesis factors, which can influence changes in state of a tissue;

incorporating effects of drugs in the pro-angiogenesis and anti-angiogenesis factors;

generating a plurality of treatment protocols space; and

selecting a best treatment protocol based on a pre-determined criteria.