BIOSENSOR MEMBRANES COMPOSED OF POLYMERS CONTAINING HETEROCYCLIC NITROGENS

• US 20080277277A1
• Filed: 07/16/2008
• Published: 11/13/2008
• Est. Priority Date: 05/15/2001
• Status: Active Grant

• Current Assignee: Abbott Diabetes Care Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Abbott Diabetes Care Incorporated (Abbott Laboratories Incorporated)
• Inventors: Cho, Hyun, MAO, FEI
• Granted Patent: US 8,380,274 B2
• Time in Patent Office: Days
• US Class Current: 204/403.06
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/1473 invasive, e.g. introduced into the body by a catheter A61B5/1482 takes precedence
• CPC Class Codes: A61B 5/14865 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
• CPC Class Codes: A61B 5/6846 specially adapted to be brought in contact with an internal body part, i.e. invasive
• CPC Class Codes: C12Q 1/002 Electrode membranes
• CPC Class Codes: C12Q 1/004 mediator-assisted
• CPC Class Codes: C12Q 1/006 for glucose

Abstract

Novel membranes comprising various polymers containing heterocyclic nitrogen groups are described. These membranes are usefully employed in electrochemical sensors, such as amperometric biosensors. More particularly, these membranes effectively regulate a flux of analyte to a measurement electrode in an electrochemical sensor, thereby improving the functioning of the electrochemical sensor over a significant range of analyte concentrations. Electrochemical sensors equipped with such membranes are also described.

Claims

1-89. -89. (canceled)

90. An electrochemical analyte sensor configured for implantation in vivo and for measuring an analyte concentration in a host, the sensor comprising:

at least one electrode; and

a membrane system located over an electroactive surface of the electrode, wherein the membrane system comprises an interference domain comprising a blend of at least one hydrophilic component and at least one hydrophobic component, wherein the interference domain is configured such that the sensor provides an equivalent analyte signal response, to at least one interferent, that does not substantially affect accuracy of an in vivo analyte concentration measurement, and wherein the sensor provides a linear response to analyte concentration, in vivo, within in a physiological range.

91. The sensor of claim 90, wherein an amount of the hydrophobic component is greater than an amount of the hydrophilic component.

92. The sensor of claim 90, wherein the interference domain is a uni-component domain comprising a polymer, and wherein the blend of at least one hydrophilic component and at least one hydrophobic component comprises at least one hydrophilic substituent of the polymer and at least one hydrophobic substituent of the polymer.

93. The sensor of claim 90, wherein the analyte is glucose, and wherein the sensor is configured to possess a glucose sensitivity of from about 1 nM to about 30 nM.

94. The sensor of claim 90, further comprising sensor electronics operably connected to the electrode and configured to provide a signal representative of an analyte concentration in the host, wherein the analyte is glucose.

95. A method of manufacturing an analyte sensor, comprising:

applying a membrane system to an electroactive surface, wherein the membrane system comprises an interference domain comprising a blend of at least one hydrophilic component and at least one hydrophobic component.

96. The method of claim 95, wherein the step of applying the membrane system comprises applying an electrode domain to the electroactive surface such that the electrode domain is more proximal to the electroactive surface than the interference domain.

97. The method of claim 96, wherein the step of applying the electrode domain comprises depositing at least one layer comprising at least one hydrophilic polymer over the electroactive surface.

98. The method of claim 97, wherein the step of applying the electrode domain comprises depositing at least two layers, each comprising at least one hydrophilic polymer, over the electroactive surface.

99. The method of claim 96, wherein the step of applying the electrode domain comprises depositing polyvinylimidazole or a copolymer thereof.

100. The method of claim 95, wherein the step of applying the membrane system comprises applying the interference domain over the electroactive surface.

101. The method of claim 100, wherein the interference domain possesses a symmetrical structure.

102. The method of claim 100, wherein the step of applying a membrane system comprises providing a solution of at least one hydrophilic component and at least one hydrophobic component in a single solvent, and casting the solution over the electroactive surface.