ARTICLES FOR TISSUE REGENERATION WITH BIODEGRADABLE POLYMER

• US 20080279824A1
• Filed: 05/10/2007
• Published: 11/13/2008
• Est. Priority Date: 05/10/2007
• Status: Active Grant

• Current Assignee: Cormatrix Cardiovascular, Inc.
• Original Assignee: Cormatrix Cardiovascular, Inc.
• Inventors: MATHENY, ROBERT G., LEWIS, BEECHER C.
• Granted Patent: US 9,034,367 B2
• Time in Patent Office: Days
• US Class Current: 424/93.1
• CPC Class Codes: A61K 38/00 Medicinal preparations containing peptides peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00
• CPC Class Codes: A61L 2430/34 for soft tissue reconstruction
• CPC Class Codes: A61L 27/14 Macromolecular materials
• CPC Class Codes: A61L 27/3604 characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
• CPC Class Codes: A61L 27/3629 Intestinal tissue, e.g. small intestinal submucosa
• CPC Class Codes: A61L 27/3633 Extracellular matrix [ECM]
• CPC Class Codes: A61L 27/3641 characterised by the site of application in the body materials for artificial blood vessels A61L27/507; materials for use in artificial skin A61L27/60
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: A61L 27/58 Materials at least partially resorbable by the body
• CPC Class Codes: A61P 17/02 for treating wounds, ulcers, burns, scars, keloids, or the like
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

The invention is to articles made from extracellular matrix sheets that encase biodegradable polymeric material. Methods of healing wounds or regenerating tissue at sites of defect by placing said articles in mammals are claimed. The biodegradable polymer can change quality upon contact with a physiological parameter such as temperature or pH that causes, for example, a liquid polymer to gel or harden. The degradation of the polymer can be controlled to suit a tissue regeneration or wound healing time course. Additional components such as proteins, cells and drugs can be added to the biopolymer composition.

Claims

1. An article comprising:

a sheet of extracellular matrix encasing a composition comprising a biodegradable polymer.

2. The article of claim 1, wherein said article comprises two or more sheets of extracellular matrix encasing said composition.

3. The article of claim 1, wherein said composition changes consistency in response to a physiological condition.

4. The article of claim 3, wherein said physiological condition is pH, temperature or enzymatic activity.

The article of claim 1, wherein said biodegradable polymer composition further comprises an additional element.

6. The article of claim 5, wherein said additional element comprises an element selected from the group consisting of a protein, cell and a drug.

10. The article of claim 6, wherein said biodegradable polymer degrades at a designed rate.

7. An article comprising:

a conduit formed of an outer tube and a concentric inner tube, each tube comprising extracellular matrix sheets, said conduit having a space between said outer tube and said inner tube, said space occupied with a composition comprising a biodegradable polymer.

8. The article of claim 7, wherein said composition changes consistency in response to a physiological condition.

9. The article of claim 8, wherein said physiological condition is pH, temperature or enzymatic activity.

11. A method comprising:

a. identifying a defect or wound in mammalian tissue in a mammal,

b. providing an article comprising extracellular matrix encasing a composition comprising a biodegradable polymer,

c. contacting said defect or wound with said article, and

d. regenerating tissue at said defect or healing said wound, whereby said composition biodegrades in said mammal.

12. The method of claim 11, wherein said mammalian tissue is myocardial tissue.

13. The method of claim 11, wherein said mammalian tissue is pancreatic tissue.

14. The method of claim 11, wherein said mammalian tissue is in liver tissue.

15. The method of claim 11, wherein said composition changes consistency in response to a physiological condition

17. The method of claim 11, wherein said article comprises a conduit formed of an outer tube and a concentric inner tube, each tube comprising extracellular matrix sheets, said conduit having a space between said outer tube and said inner tube, said space occupied with a composition comprising a biodegradable polymer.

18. The method of claim 11, wherein said article comprises a sandwich configuration of two sheets of extracellular matrix encasing a composition comprising a biodegradable polymer.

19. The method of claim 11, said composition further comprising an additional element.

20. The method of claim 19, wherein said additional element is an element selected from the group consisting of a protein, a cell and a drug.

16. The method of claim 16, wherein said physiological condition is pH, temperature or enzymatic activity.