Composite hydrogel drug delivery systems
First Claim
1. A method of making a gel, the method comprising reacting hydrophilic, synthetic macromers with each other through covalent reactions to form a continuous, bioabsorbable, synthetic, covalently crosslinked hydrogel matrix in the presence of hydrophobic materials and a therapeutic agent, with a plurality of hydrophobic domains being formed from the hydrophobic materials and dispersed in the continuous hydrogel matrix, with the therapeutic agent being associated with the hydrophobic domains.
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Abstract
Compositions and methods are provided to control the release of relatively low molecular weight therapeutic species through hydrogels by first dispersing or dissolving such therapeutic species within relatively hydrophobic rate modifying agents to form a mixture. The mixture is formed into microparticles that are dispersed within bioabsorbable hydrogels, so as to release the water soluble therapeutic agents in a controlled fashion. Methods of using the compositions of the present invention in therapeutic systems are also provided.
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Citations
25 Claims
- 1. A method of making a gel, the method comprising reacting hydrophilic, synthetic macromers with each other through covalent reactions to form a continuous, bioabsorbable, synthetic, covalently crosslinked hydrogel matrix in the presence of hydrophobic materials and a therapeutic agent, with a plurality of hydrophobic domains being formed from the hydrophobic materials and dispersed in the continuous hydrogel matrix, with the therapeutic agent being associated with the hydrophobic domains.
Specification