NANOPARTICULATE COMPOSITIONS OF ANGIOGENESIS INHIBITORS
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Abstract
Nanoparticulate compositions comprising at least one poorly soluble angiogenesis inhibitor and at least one surface stabilizer are described. The nanoparticulate compositions have an average particle size of less than about 2000 nm. The invention also describes methods of making and using such compositions.
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Citations
148 Claims
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1-86. -86. (canceled)
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87. An angiogenesis inhibitor composition consisting of:
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(a) particles of an angiogenesis inhibitor, wherein the angiogenesis inhibitor is paclitaxel or a salt thereof, having an effective average particle size of less than about 2000 nm; and (b) associated with the surface thereof at least one surface stabilizer, wherein the surface stabilizer is essentially free of intermolecular cross linkages. - View Dependent Claims (88, 89, 90, 91, 93, 94, 95, 96, 97, 98, 99, 100, 101, 102, 103, 104, 105, 106, 107, 145)
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92. An angiogenesis inhibitor composition consisting of:
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(a) particles of an angiogenesis inhibitor, wherein the angiogenesis inhibitor is paclitaxel or a salt thereof, having an effective average particle size of less than about 2000 nm; (b) associated with the surface thereof at least one surface stabilizer, wherein the surface stabilizer is essentially free of intermolecular cross linkages; and (c) one or more pharmaceutically acceptable excipients, carriers, or a combination thereof.
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- 108. A method of making a solvent-free angiogenesis inhibitor composition comprising contacting particles of at least one angiogenesis inhibitor, wherein the angiogenesis inhibitor is paclitaxel or a salt thereof, with at least one surface stabilizer, wherein the surface stabilizer is essentially free of intermolecular cross linkages, for a time and under conditions sufficient to provide an angiogenesis inhibitor composition having an effective average particle size of less than about 2 microns.
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120. A method of treating a subject in need with an angiogenesis inhibitor composition comprising administering to the subject an effective amount of a solvent-free angiogenesis inhibitor composition consisting of:
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(a) particles of an angiogenesis inhibitor, wherein the angiogenesis inhibitor is paclitaxel or a salt thereof, having an effective average particle size of less than about 2000 nm; and (b) associated with the surface thereof at least one surface stabilizer, wherein the surface stabilizer is essentially free of intermolecular cross linkages. - View Dependent Claims (121, 122, 123, 124, 125, 126, 127, 128, 129, 130, 131, 132, 133, 134, 135, 136, 137, 138, 139, 140, 141, 142, 143, 144, 147)
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148. A neoplastic inhibitor composition comprising:
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(a) particles of a neoplastic inhibitor or a salt thereof having an effective average particle size of less than about 2000 nm; and (b) associated with the surface thereof at least one non-crosslinked surface stabilizer.
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Specification