METHODS FOR THE PRODUCTION OF SENSOR ARRAYS USING ELECTRICALLY ADDRESSABLE ELECTRODES
First Claim
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1. A method for selectively modifying electrodes derivatized with a first functional group in an array of electrically addressable electrodes, the method comprising:
- (a) applying a potential to at least one electrically addressable electrode to electrochemically reduce the first functional group to provide a second functional group; and
(b) exposing the second functional group to a binding entity that reacts with the second functional group but not with the first functional group, whereby the binding entity becomes bound to the at least one electrode.
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Abstract
Methods for building sensor arrays using electrical signals to selectively functionalize individual electrodes in an array of electrically addressable electrodes are provided. These methods are useful for providing sensor arrays for use in chemical and biochemical assays. The method is based on the sequential electrochemical reduction of functional groups on individual electrodes in order to selectively promote the functionalization of selected electrodes with selected binding entities.
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25 Claims
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1. A method for selectively modifying electrodes derivatized with a first functional group in an array of electrically addressable electrodes, the method comprising:
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(a) applying a potential to at least one electrically addressable electrode to electrochemically reduce the first functional group to provide a second functional group; and (b) exposing the second functional group to a binding entity that reacts with the second functional group but not with the first functional group, whereby the binding entity becomes bound to the at least one electrode. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25)
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Specification