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Compositions and Methods for Treating Vascular Permeability

  • US 20080280811A1
  • Filed: 02/16/2006
  • Published: 11/13/2008
  • Est. Priority Date: 02/24/2005
  • Status: Active Grant
First Claim
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1. A method of decreasing retinal vascular permeability in the eye of a subject, the method comprising administering to the subject a therapeutically effective amount of one or more of:

  • (i) an inhibitor of Carbonic Anhydrase-1 (CA-1) and/or Carbonic Anhydrase-2 (CA-2) signaling and optionally an inhibitor of Vascular Endothelial Growth Factor (VEGF) signalling;

    (ii) an inhibitor of a kallikrein/kinin pathway; and

    /or(iii) a Complement-1 Inhibitor (C1-INH) agonist.

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