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Methods and Compositions Using Certain Phenolic Derivatives for the Treatment of Diabetes

  • US 20080280985A1
  • Filed: 03/26/2008
  • Published: 11/13/2008
  • Est. Priority Date: 03/27/2007
  • Status: Abandoned Application
First Claim
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1. A method for the treatment or prophylaxis of diabetes, a pre-diabetes condition or a diabetes related disorder in a host, comprising administering a compound of formula (X-1), or a pharmaceutically acceptable salt, ester, pharmaceutically acceptable derivative, or prodrug thereof, is provided wherein X is S, Se, S(O) and S(O)2;

  • Y is S, Se, S(O) and S(O)2;

    A comprises one or more groups selected from optionally substituted C1-6 alkylene, optionally substituted C2-6 alkenylene; and

    optionally substituted C3-10 cycloalkylene;

    n is 0 or 1;

    R1, R2, R3, R4, R5, R6, R7, R8, R9 and R10 may be the same or different and are independently selected from the group consisting of hydrogen, halogen, hydroxyl, thiol, —

    NR11R12, nitro, cyano, optionally substituted C1-10 alkyl, optionally substituted C2-10 alkenyl, optionally substituted C2-10 alkynyl, optionally substituted C3-10 cycloalkyl, optionally substituted aryl, optionally substituted aryl(C1-6 alkyl), optionally substituted (C1-6 alkyl)aryl, optionally substituted heteroaryl, optionally substituted C3-10 heterocycloalkyl, C(O)R11, OR12, CH2OR12, CH2NR13R14, C(O)OR12 and C(O)NR13R14;

    R11 is selected from OH, C1-6 alkyl, and C1-6 alkenyl;

    R12 is selected from the group consisting of hydrogen, optionally substituted C1-10 alkyl, optionally substituted C2-10 alkenyl, optionally substituted C2-10-alkynyl, optionally substituted C3-10 cycloalkyl, optionally substituted aryl, —

    C(O)(C1-6)alkyl-CO2R15, —

    C(O)(C2-6)alkenyl-CO2R15, and —

    C(O)NR13R14;

    R13 and R14 may be the same or different and are individually selected from hydrogen, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-6 cycloalkyl, C3-6 heterocycloalkyl, aryl, (C1-6)alkylaryl, and heteroaryl; and

    R15 is H or C1-4 alkyl.

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