Reversibly Masked Polymers
First Claim
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1. A reversibly masked membrane active polymer comprising:
- a plurality of masking agents covalently linked to said membrane active polymer via physiologically labile bonds wherein the masking agents inhibit membrane activity of the membrane active polymer.
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Abstract
The present invention is directed to reversibly inactivation of membrane active polymers useful for cellular delivery of compounds. Described are polyconjugates systems that incorporate targeting, anti-opsonization, anti-aggregation, and transfection activities into small biocompatible in vivo delivery conjugates. The use of multiple reversible linkages connecting component parts provides for physiologically responsive activity modulation.
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Citations
28 Claims
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1. A reversibly masked membrane active polymer comprising:
- a plurality of masking agents covalently linked to said membrane active polymer via physiologically labile bonds wherein the masking agents inhibit membrane activity of the membrane active polymer.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28)
Specification