BREAST IMPLANTS AND COMPOSITIONS OF EXTRACELLULAR MATRIX

• US 20080281419A1
• Filed: 05/10/2007
• Published: 11/13/2008
• Est. Priority Date: 05/10/2007
• Status: Abandoned Application

• Current Assignee: Cormatrix Cardiovascular, Inc.
• Original Assignee: Cormatrix Cardiovascular, Inc.
• Inventors: Firestone, Leigh H., MATHENY, Robert G.
• Application Number:
  US11/746,981
• Publication Number:
  US 20080281419A1
• Time in Patent Office: Days
• US Class Current: 623/8
• CPC Class Codes: A61F 2/0059 Cosmetic or alloplastic implants A61F2/10 - A61F2/16, A61F2/28 take precedence
• CPC Class Codes: A61F 2/12 Mammary prostheses and implants
• CPC Class Codes: A61L 2430/04 for mammary reconstruction
• CPC Class Codes: A61L 27/3633 Extracellular matrix [ECM]
• CPC Class Codes: A61L 27/3641 characterised by the site of application in the body materials for artificial blood vessels A61L27/507; materials for use in artificial skin A61L27/60
• CPC Class Codes: A61L 27/3839 characterised by the site of application in the body materials for artificial blood vessels A61L27/507; materials for use in artificial skin A61L27/60

Abstract

The invention is articles and compositions of extracellular matrix for forming breast implants and otherwise augmenting or reconstructing breast tissue and other cosmetically desired tissue in humans, such as lips and cheeks. The invention is also to methods of using these in implant articles to augment or reconstruct a human breast or other tissue.

Claims

1. An article for placing in a human breast comprising:

one or more sheets of mammalian extracellular matrix encasing a composition comprising extracellular matrix in an emulsion, gel, paste, liquid or particulate form, wherein the article forms an implant shaped to conform to a shape of a human breast.

2. The article of claim 1, wherein said encased composition comprises a concentration of extracellular matrix greater than about 0.001 mg/ml.

3. The article of claim 1, wherein said encased composition comprises a concentration of extracellular matrix in a range from about 0.001 mg/ml to about 200 mg/ml.

4. The article of claim 1, wherein said encased composition comprises extracellular matrices from two or more mammalian tissue sources.

5. The article of claim 1, wherein said sheets of extracellular matrix comprise small intestine submucosa, or stomach submucosa.

6. The article of claim 1, wherein said encased composition further comprises an additional component.

7. The article of claim 6, wherein said additional component is a cell.

8. The article of claim 7, wherein said cell is a stem cell.

9. The article of claim 6, wherein said additional component is a protein.

10. The article of claim 9, wherein said protein is a growth factor.

11. The article of claim 6, wherein said additional component is a drug.

12. A method of augmenting or reconstructing a human breast comprising:

a. providing an article comprising one or more sheets of mammalian extracellular matrix encasing a composition comprising extracellular matrix in an emulsion, gel, paste, liquid or particulate form, wherein said article forms an implant shaped to conform to a shape of a human breast, and

b. placing said article in a human breast.

13. The method of claim 12, wherein said sheets comprise small intestine submucosa or stomach submucosa.

14. The method of claim 12, wherein said encased composition comprises extracellular matrices from two or more mammalian tissue sources.

15. The method of claim 12, wherein said encased composition further comprises an additional component.

16. The method of claim 15, wherein said additional component is a cell.

17. A method of augmenting tissue at a site in the human body comprising:

a). providing a composition comprising mammalian extracellular matrix, and

b) introducing said composition into said human body in sufficient amount to generate new tissue at said site, resulting in an augmentation of tissue at said site.

18. The method of claim 17, wherein said composition comprises extracellular matrix from more than one mammalian tissue source.

19. The method of claim 17, wherein said composition comprises extracellular matrix in a concentration greater than about 0.001 mg/ml.

20. The method of claim 17, wherein said site in said human body is a breast.