Methods of Detecting Ovarian Cancer
First Claim
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1. A method for facilitating the diagnosis of a subject for a cancer of mullerian origin, comprising detecting a presence or an absence of an Elafin polypeptide in a sample from said subject, wherein the presence of said Elafin polypeptide indicates of the presence of a cancer of mullerian origin in said subject.
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Abstract
The present invention provides methods of detecting ovarian cancer using biomarkers.
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36 Claims
- 1. A method for facilitating the diagnosis of a subject for a cancer of mullerian origin, comprising detecting a presence or an absence of an Elafin polypeptide in a sample from said subject, wherein the presence of said Elafin polypeptide indicates of the presence of a cancer of mullerian origin in said subject.
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15. A method for monitoring the progression of a mullerian derived cancer in a patient, comprising
a) detecting the presence of an Elafin polypeptide in a first sample from said patient at a first period of time, b) detecting the presence of the Elafin polypeptide in a second sample from said patient at a second period of time c) comparing the amount of polypeptide detected in step (a) to the amount detected in step (b), wherein the cancer is progressing if the amount of the polypeptide increases over time, whereas the cancer is not progressing if the amount of the polypeptide remains constant or decreases over time.
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23. A method of diagnosing a mullerian derived cancer in a subject comprising:
- detecting the presence of an Elafin polypeptide in a sample from the subject;
determining the level of the Elafin polypeptide in said sample to provide a test value; and
comparing the test value to a standard value, wherein a test value above the standard value is indicative of a mullerian derived cancer. - View Dependent Claims (24, 25, 26, 27, 28)
- detecting the presence of an Elafin polypeptide in a sample from the subject;
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29. A method of screening for the presence of ovarian cancer in a subject, comprising contacting a sample taken from said subject with an anti-Elafin antibody under conditions permitting said antibody to specifically bind an antigen in the sample to form an antibody-antigen complex;
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determining the amount of antibody-antigen complex in the sample as a measure of the amount of antigen in the sample, wherein an elevated level of the antigen in the sample indicates the presence of ovarian cancer. - View Dependent Claims (30, 31, 32, 33)
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- 34. A method of alleviating a symptom of a mullerian-derived tumor comprising administering to a subject in need thereof an anti-Elafin antibody linked to a toxin.
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36. A kit comprising in one or more containers, an Elafin antibody, a detection reagent and instructions.
Specification