Composition comprising licorice polyphenol

• US 20080286254A1
• Filed: 05/16/2008
• Published: 11/20/2008
• Est. Priority Date: 05/17/2007
• Status: Abandoned Application

• Current Assignee: Kaneka Corporation
• Original Assignee: Kaneka Corporation
• Inventors: Kitamura, Shiro, Tominaga, Yuji, Yokota, Shinichi, Sakamoto, Hirokazu
• Application Number:
  US12/153,371
• Publication Number:
  US 20080286254A1
• Time in Patent Office: Days
• US Class Current: 424/93.45
• CPC Class Codes: A23D 9/007 characterised by ingredients other than fatty acid triglycerides
• CPC Class Codes: A23K 20/111 Aromatic compounds
• CPC Class Codes: A23K 50/40 for carnivorous animals, e.g. cats or dogs
• CPC Class Codes: A23L 33/105 Plant extracts, their artificial duplicates or their derivatives
• CPC Class Codes: A23V 2002/00 Food compositions, function of food ingredients or processes for food or foodstuffs
• CPC Class Codes: A23V 2200/328 having effect on glycaemic control and diabetes
• CPC Class Codes: A23V 2250/2132 Other phenolic compounds, polyphenols
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 36/06 Fungi, e.g. yeasts
• CPC Class Codes: A61K 36/45 Ericaceae or Vacciniaceae (Heath or Blueberry family), e.g. blueberry, cranberry or bilberry
• CPC Class Codes: A61K 36/484 Glycyrrhiza (licorice)
• CPC Class Codes: A61K 36/67 Piperaceae (Pepper family), e.g. Jamaican pepper or kava
• CPC Class Codes: A61K 36/73 Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
• CPC Class Codes: A61K 36/74 Rubiaceae (Madder family)
• CPC Class Codes: A61K 36/752 Citrus, e.g. lime, orange or lemon
• CPC Class Codes: A61K 36/82 Theaceae (Tea family), e.g. camellia
• CPC Class Codes: A61K 36/87 Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
• CPC Class Codes: A61K 36/9068 Zingiber, e.g. garden ginger
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61P 17/16 Emollients or protectives, e.g. against radiation
• CPC Class Codes: A61P 17/18 : Antioxidants, e.g. antiradicals preparations for protection against sunlight A61Q17/00
• CPC Class Codes: A61P 3/00 : Drugs for disorders of the metabolism of the blood or the extracellular fluid A61P7/00
• CPC Class Codes: A61P 3/02 : Nutrients, e.g. vitamins, minerals
• CPC Class Codes: A61P 3/04 : Anorexiants; Antiobesity agents
• CPC Class Codes: A61P 3/06 : Antihyperlipidemics
• CPC Class Codes: A61P 3/10 : for hyperglycaemia, e.g. antidiabetics
• CPC Class Codes: A61P 39/06 : Free radical scavengers or antioxidants
• CPC Class Codes: A61P 9/12 : Antihypertensives

Abstract

A composition containing a licorice polyphenol and other active ingredient (antioxidant ingredient, polyphenol other than licorice polyphenol or a component relating to lipid absorption or metabolism) is highly safe, can be produced easily, and can be utilized for foods and drinks such as health food, food with health claims (specified health food, food with nutrient function claims) and the like, pharmaceutical products, quasi-drugs, cosmetics and the like. In addition, since the composition has a body fat accumulation suppressing effect, a body fat decomposition promoting effect or energy production promoting effect, it is useful for the treatment of obesity, metabolic syndrome and the like.

Claims

1. A composition comprising licorice polyphenol and an antioxidant ingredient.

2. The composition of claim 1, wherein the antioxidant ingredient is at least one kind selected from the group consisting of a-lipoic acid, glutathione, astaxanthin, lycopene, taurine, methionine, S-adenosylmethionine, cysteine, cystine, thiol compound, reducing sugar, sesamin, capsaicin, citric acid, pycnogenol, fucoxanthin, lignan, piperine, policosanol, anthocyanin, proanthocyanidin, chlorogenic acid, vitamin C, vitamin A, vitamin E and carotenoid.

11. The composition of claim 1, further comprising vitamin or a vitamin-like component.

12. The composition of claim 11, wherein the vitamin or vitamin-like component is at least one kind selected from the group consisting of vitamin B, vitamin K, folic acid and inositol.

13. The composition of claim 1, further comprising an amino acid or an amino acid derivative.

14. The composition of claim 13, wherein the amino acid or amino acid derivative is at least one kind selected from the group consisting of alanine, valine, leucine, isoleucine, glycine, proline, glutamine, glutamic acid, asparagine, aspartic acid, arginine, lysine, citrulline, ornithine and derivatives thereof.

15. The composition of claim 1, comprising licorice polyphenol in the form of a licorice hydrophobic extract.

16. The composition of claim 1, wherein the licorice polyphenol comprises at least glabridin.

17. The composition of claim 16, wherein the content of glycyrrhizin in the composition is not more than the content of glabridin.

18. The composition of claim 1, further comprising medium chain fatty acid triglyceride.

19. The composition of claim 1, which is a body fat accumulation suppressor.

20. The composition of claim 1, which is a body fat decomposition promoter.

21. The composition of claim 1, which is an energy production promoter.

22. The composition of claim 1, which is used for the treatment of obesity, metabolic syndrome, diabetes, hyperlipidemia or hypertension.

23. The composition of claim 1, which is used for a food, drink, functional food, nutritional supplement, pharmaceutical product, quasi-drug, cosmetic, animal drug, pet food, feed or prey feed.

24. The composition of claim 1, which is used in combination with a pharmaceutical product to be used for the treatment of obesity, metabolic syndrome, diabetes, hyperlipidemia or hypertension.

25. The composition of claim 1, which is a preparation for oral administration.

26. A method for promoting an energy production, comprising administering an effective amount of the composition of claim 1 to a subject.

27. A method for the prophylaxis, improvement or treatment of obesity, metabolic syndrome, diabetes, hyperlipidemia or hypertension, comprising administering an effective amount of the composition of claim 1 to a subject.

28. A method for becoming slim, comprising administering an effective amount of the composition of claim 1 to a subject.

3. A composition comprising licorice polyphenol and polyphenol other than licorice polyphenol.

4. The composition of claim 3, wherein the polyphenol other than licorice polyphenol is at least one kind selected from the group consisting of genistein, daidzein, quercetin, rutin, catechin, epigallocatechin gallate, hesperidin, nobiletin, tyrosol, hydroxytyrosol, oleuropein, naringenin, caffeic acid, apple polyphenol, tea polyphenol and gallic acid.

5. A composition comprising licorice polyphenol and a component relating to absorption or metabolism of lipid.

6. The composition of claim 5, wherein the component relating to the absorption or metabolism of lipid is a lipid absorption inhibitory component.

7. The composition of claim 6, wherein the lipid absorption inhibitory component is at least one kind selected from the group consisting of lactobacillus, yeast, polysaccharides, dietary fiber, oligosaccharide, inulin, chitin, chitosan, phytosterol, pectin, glucosamine, N-acetylglucosamine, hyaluronan, chondroitin sulfate, sodium alginate and tannin.

8. The composition of claim 5, wherein the component relating to the absorption or metabolism of lipid is a component modifying lipid metabolism in cells.

9. The composition of claim 8, wherein the component modifying lipid metabolism in cells is at least one kind selected from the group consisting of carnitine, capsaicin, malic acid, hydroxycitric acid, acetic acid, propionic acid, citric acid, sesamin, pyruvic acid, curcuminoid, gingerol, pycnogenol, resveratrol, soybean protein, conjugated linoleic acid, catechin, caffeine, fucoxanthin, diacylglycerol, glucomannan, lignan, fructooligosaccharide, piperine, policosanol, chrome, zinc, vanadium, phospholipid and highly-unsaturated fatty acid.

10. The composition of claim 8, wherein the component modifying lipid metabolism in cells is at least one kind selected from the group consisting of chili pepper, tea, fermented tea, coffee, pepper, garcinia cambogia, ginger, blueberry, citrus, grape and extracts thereof.