OCULAR IMPLANT MADE BY A DOUBLE EXTRUSION PROCESS
First Claim
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1. A method for making a bioerodible implant for treating an ocular condition of the eye, the method comprising a plurality of extrusions of a biodegradable polymer.
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Abstract
The invention provides biodegradable implants sized for implantation in an ocular region and methods for treating medical conditions of the eye. The implants are formed from a mixture of hydrophilic end and hydrophobic end PLGA, and deliver active agents into an ocular region without a high burst release.
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8 Claims
- 1. A method for making a bioerodible implant for treating an ocular condition of the eye, the method comprising a plurality of extrusions of a biodegradable polymer.
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7. A method for making a bioerodible implant for treating an ocular condition, the method comprising the steps of:
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(a) milling a biodegradable polymer; (b) blending the milled biodegradable polymer and particles of an active agent, to thereby obtain a blended mixture of the milled biodegradable polymer and the particles of the active agent, wherein at least about 75% of the particles of the active agent have a diameter of less than about 20 μ
m;(c) carrying out a first extrusion of the blended mixture, to thereby obtain a first extrusion product; (d) pelletizing the first extrusion product, and; (e) carrying out a second extrusion of the pelletized first extrusion product, thereby obtaining a bioerodible implant for an ocular condition.
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Specification