SYSTEMS, DEVICES, AND METHODS FOR PASSIVE TRANSDERMAL DELIVERY OF ACTIVE AGENTS TO A BIOLOGICAL INTERFACE
First Claim
Patent Images
1. A passive transdermal delivery device comprising:
- a backing substrate; and
an active agent layer, wherein the active agent layer is substantially anhydrous and oil-free and includes a thickening agent and an ionizable active agent, and wherein the ionizable active agent is electrically neutral in the active agent layer and dissociates into an ionized active agent upon contacting an aqueous medium.
2 Assignments
0 Petitions
Accused Products
Abstract
Systems, devices, and methods for transdermal delivery of one or more therapeutic active agents to a biological interface. A transdermal drug delivery system is provided for passive transdermal delivery of one or more ionizable active agents to a biological interface of a subject. A transdermal drug delivery system includes a backing substrate, and an active agent layer. The active layer includes a thickening agent, a plasticizer, and a therapeutically effective amount of an ionizable active agent.
-
Citations
29 Claims
-
1. A passive transdermal delivery device comprising:
-
a backing substrate; and an active agent layer, wherein the active agent layer is substantially anhydrous and oil-free and includes a thickening agent and an ionizable active agent, and wherein the ionizable active agent is electrically neutral in the active agent layer and dissociates into an ionized active agent upon contacting an aqueous medium. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
-
-
21. A topical formulation comprising:
-
a thickening agent, an ionized active agent; and an aqueous medium, wherein the topical formulation is substantially oil-free. - View Dependent Claims (22, 23)
-
-
24. A method of treating a condition associated with an obstructive respiratory ailment in a subject comprising:
-
applying to the subject'"'"'s skin a passive transdermal delivery device comprising;
a backing substrate; and
an active agent layer, wherein the active agent layer is substantially anhydrous and oil-free and includes a thickening agent and an ionizable active agent, and wherein the ionizable active agent is electrically neutral in the active agent layer and dissociates into an ionized active agent upon contacting an aqueous medium; andallowing the ionizable active agent to dissociate into the ionized active agent. - View Dependent Claims (25, 26, 27, 28, 29)
-
Specification