Sequencing a Polymer Molecule
First Claim
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1. A method for sequencing a target polymer molecule, comprising the steps of:
- (i) treating the target polymer with an agent that degrades sequentially at least one end of the target polymer;
(ii) converting at least a portion of the degraded end of different degraded polymers into a readable signal sequence, and labeling each of said degraded polymers with a tag that represents the relative order of degradation;
(iii) determining the sequence of the readable signal sequence; and
(iv) determining the sequence of the target polymer using the sequence data obtained in step (iii) and the identification of each associated tag.
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Abstract
A method for sequencing a target polymer molecule comprises the steps of: (i) treating the target polymer with an agent that degrades sequentially at least one end of the target polymer; (ii) converting at least a portion of the degraded end of different degraded polymers into a readable signal sequence, and labeling each of said degraded polymers with a tag that represents the relative order of degradation; (iii) determining the sequence of the readable signal sequence; and (iv) determining the sequence of the target polymer using the sequence data obtained in step (iii) and the identification of each associated tag.
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Citations
12 Claims
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1. A method for sequencing a target polymer molecule, comprising the steps of:
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(i) treating the target polymer with an agent that degrades sequentially at least one end of the target polymer; (ii) converting at least a portion of the degraded end of different degraded polymers into a readable signal sequence, and labeling each of said degraded polymers with a tag that represents the relative order of degradation; (iii) determining the sequence of the readable signal sequence; and (iv) determining the sequence of the target polymer using the sequence data obtained in step (iii) and the identification of each associated tag. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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Specification