Nucleotide analogs
First Claim
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1. A nucleotide analog, comprisingA nitrogenous base;
- A linker attached at the N4, N6, O4, or O6 of said nitrogenous base; and
An optically-detectable label attached to said nitrogenous base via said linker.
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Abstract
The disclosure provides nucleotide analogs and methods of their use. Analogs of the invention comprise a reporter molecule (label) attached via the N4, N6, O4, or O6 position of the nitrogenous base portion of the analog. In a preferred embodiment, nucleotide analogs of the invention comprise a label attached to the nitrogenous base portion of the analog via a cleavable linker at the N4, O4, N6 or O6 position.
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Citations
16 Claims
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1. A nucleotide analog, comprising
A nitrogenous base; -
A linker attached at the N4, N6, O4, or O6 of said nitrogenous base; and An optically-detectable label attached to said nitrogenous base via said linker. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
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Specification