Method of Inducing Embryonic Stem Cells Into Pancreatic Cells
First Claim
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1. A method for inducing embryonic stem cell, comprising in sequence the steps of:
- culturing embryonic stem cells in a cell culture medium to form embryonic bodies;
incubating the embryonic bodies with Activin A; and
incubating the embryonic bodies with RA to develop insulin-producing precursor cells.
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Abstract
The present invention provided a simple three-step approach based on the combinational induction with activin A, all-trans retinoic acid and, optionally, other maturation factors which are able to induce embryonic stem cells to differentiate into insulin-producing cells. A kit used to induce embryonic stem cells to differentiate into insulin-producing cells was also provided.
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Citations
15 Claims
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1. A method for inducing embryonic stem cell, comprising in sequence the steps of:
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culturing embryonic stem cells in a cell culture medium to form embryonic bodies; incubating the embryonic bodies with Activin A; and
incubating the embryonic bodies with RA to develop insulin-producing precursor cells. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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- 12. A kit for inducing embryonic stem cell, comprising Activin A and RA.
Specification